TY - JOUR
T1 - Age-associated changes in skeletal muscles and their effect on mobility
T2 - An operational diagnosis of sarcopenia
AU - Lauretani, Fulvio
AU - Russo, Cosimo Roberto
AU - Bandinelli, Stefania
AU - Bartali, Benedetta
AU - Cavazzini, Chiara
AU - Di Iorio, Angelo
AU - Corsi, Anna Maria
AU - Rantanen, Taina
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
PY - 2003/11
Y1 - 2003/11
N2 - Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to identify persons with impaired muscle function are still lacking. Using data from a large representative sample of the general population, we examined how muscle function and calf muscle area change with aging and affect mobility in men and women free of neurological conditions. We tested several putative indicators of sarcopenia, including knee extension isometric torque, handgrip, lower extremity muscle power, and calf muscle area. For each indicator, sarcopenia was considered to be present when the measure was >2 SDs below the mean. For all four measures, the prevalence of sarcopenia increased with age, both in men and women. The age-associated gradient in prevalence was maximum for muscle power and minimum for calf-muscle area. However, lower extremity muscle power was no better than knee-extension torque or handgrip in the early identification of poor mobility, defined either as walking speed
AB - Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to identify persons with impaired muscle function are still lacking. Using data from a large representative sample of the general population, we examined how muscle function and calf muscle area change with aging and affect mobility in men and women free of neurological conditions. We tested several putative indicators of sarcopenia, including knee extension isometric torque, handgrip, lower extremity muscle power, and calf muscle area. For each indicator, sarcopenia was considered to be present when the measure was >2 SDs below the mean. For all four measures, the prevalence of sarcopenia increased with age, both in men and women. The age-associated gradient in prevalence was maximum for muscle power and minimum for calf-muscle area. However, lower extremity muscle power was no better than knee-extension torque or handgrip in the early identification of poor mobility, defined either as walking speed
KW - Elderly
KW - Muscle power
KW - Strength
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M3 - Article
C2 - 14555665
AN - SCOPUS:10744233728
SN - 8750-7587
VL - 95
SP - 1851
EP - 1860
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 5
ER -