Age-associated changes in left ventricular diastolic performance during isometric exercise in normal subjects

Christian J. Swinne, Edward P. Shapiro, Sandra D. Lima, Jerome L. Fleg

Research output: Contribution to journalArticlepeer-review

Abstract

Although systolic left ventricular (LV) function at rest has been shown to be unaffected by advancing age,1,2 numerous investigations have demonstrated an age-associated decline in early diastolic filling rate, initially determined from the mitral valve E F closure slope,1,3 and more recently by Doppler-derived peak Ewave velocity4-6 and radionuclide ventriculographic peak filling rate.7,8 Conversely, by both of these latter techniques older subjects show an augmented atrial contribution to LV filling. As a result, end-diastolic volume at rest is unaffected by age.1,2 In contrast to LV diastolic function at rest, little is known about the effect of age on diastolic function during isometric exercise. Such exercise imposes an afterload stress,9-11 which might have significant effects on diastolic function. The increase in blood pressure during isometric handgrip has been shown to be exaggerated in older persons.12-13 The present study was therefore designed to evaluate the effects of age on LV diastolic response to sustained handgrip in normal subjects.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalThe American journal of cardiology
Volume69
Issue number8
DOIs
StatePublished - Mar 15 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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