Age as a determinant factor for endotoxin induced uveitis

Beatriz E. Brito, Junedy C. Marcano, Eva Salazar, Marisol Cano, Leslie Baute, Geraldine Bernal, Luis R. Gonzalez

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To determine if susceptibility to systemic endotoxin-induced uveitis is an age-related phenomenon in the rabbit. Methods: Young and adult rabbits were injected intravenously with 2.5 μg/kg of E. coli endotoxin or saline. Thereafter, the number of exudating cells at 2, 6, 12, 24 and 48 hours were determined. The levels of lipopolysaccharide-binding protein, total protein, prostaglandin-E2, nitric oxide and interleukin-6 in aqueous humor were also determined 24 hours after the injections. Results: A significant increase in the number of exudating cells and the levels of lipopolysaccharide-binding protein, total protein, prostaglandin-E2 and nitric oxide in aqueous humor was observed only in adult rabbits 24 hours after endotoxin injection. No differences were observed in the increased IL-6 levels. Conclusions: Life stage seems to be a critical factor in developing an eye-inflammatory response induced by systemic endotoxin. This could be a consequence of a differential specific activation of the ocular immune response.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalOcular Immunology and Inflammation
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Keywords

  • Cell exudation
  • Endotoxin-induced uveitis
  • Nitric oxide
  • Prostaglandin-E2
  • Rabbits

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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