Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii Aging with HIV Cohort

V. Valcour, C. Shikuma, B. Shiramizu, M. Watters, P. Poff, O. A. Selnes, J. Grove, Y. Liu, K. B. Abdul-Majid, S. Gartner, N. Sacktor

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


There are discrepant findings regarding the risk of HIV-associated dementia (HAD) relating to apolipoprotein E4, suggesting other factors may modulate risk. Furthermore, evidence suggests a changing phenotype of HAD in the era of highly active antiretroviral therapy (HAART), prompting a need to determine if new disease markers have emerged. In this analysis, APOE genotype was determined for 182 participants enrolled in the Hawaii Aging with HIV Cohort. After controlling for age and diabetes status, an independent risk of HAD relating to E4 was seen in older participants [OR=2.898 (1.031-8.244)] but not in younger participants [OR=0.373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-2 SPEC. ISS.
StatePublished - Dec 2004


  • Aging
  • Apolipoprotein
  • HIV-associated dementia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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