Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii Aging with HIV Cohort

V. Valcour; C. Shikuma; B. Shiramizu; M. Watters; P. Poff; O. A. Selnes; J. Grove; Y. Liu; K. B. Abdul-Majid; S. Gartner; N. Sacktor

doi:10.1016/j.jneuroim.2004.08.029

Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii Aging with HIV Cohort

V. Valcour, C. Shikuma, B. Shiramizu, M. Watters, P. Poff, O. A. Selnes, J. Grove, Y. Liu, K. B. Abdul-Majid, S. Gartner, N. Sacktor

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97 Scopus citations

Abstract

There are discrepant findings regarding the risk of HIV-associated dementia (HAD) relating to apolipoprotein E4, suggesting other factors may modulate risk. Furthermore, evidence suggests a changing phenotype of HAD in the era of highly active antiretroviral therapy (HAART), prompting a need to determine if new disease markers have emerged. In this analysis, APOE genotype was determined for 182 participants enrolled in the Hawaii Aging with HIV Cohort. After controlling for age and diabetes status, an independent risk of HAD relating to E4 was seen in older participants [OR=2.898 (1.031-8.244)] but not in younger participants [OR=0.373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART.

Original language	English (US)
Pages (from-to)	197-202
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	157
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jneuroim.2004.08.029
State	Published - Dec 2004

Keywords

Aging
Apolipoprotein
HIV-associated dementia

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2004.08.029

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title = "Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii Aging with HIV Cohort",

abstract = "There are discrepant findings regarding the risk of HIV-associated dementia (HAD) relating to apolipoprotein E4, suggesting other factors may modulate risk. Furthermore, evidence suggests a changing phenotype of HAD in the era of highly active antiretroviral therapy (HAART), prompting a need to determine if new disease markers have emerged. In this analysis, APOE genotype was determined for 182 participants enrolled in the Hawaii Aging with HIV Cohort. After controlling for age and diabetes status, an independent risk of HAD relating to E4 was seen in older participants [OR=2.898 (1.031-8.244)] but not in younger participants [OR=0.373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART.",

keywords = "Aging, Apolipoprotein, HIV-associated dementia",

author = "V. Valcour and C. Shikuma and B. Shiramizu and M. Watters and P. Poff and Selnes, {O. A.} and J. Grove and Y. Liu and Abdul-Majid, {K. B.} and S. Gartner and N. Sacktor",

note = "Funding Information: This work was supported by NIH grant 1U54NS43049 with additional support from P20RR11091 and G12 RR/AI 03061. Special thanks to Eric Eisenhardt, Andrew Williams, our participants, and community physicians. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2004",

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doi = "10.1016/j.jneuroim.2004.08.029",

language = "English (US)",

volume = "157",

pages = "197--202",

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AU - Valcour, V.

AU - Shikuma, C.

AU - Shiramizu, B.

AU - Watters, M.

AU - Poff, P.

AU - Selnes, O. A.

AU - Grove, J.

AU - Liu, Y.

AU - Abdul-Majid, K. B.

AU - Gartner, S.

AU - Sacktor, N.

N1 - Funding Information: This work was supported by NIH grant 1U54NS43049 with additional support from P20RR11091 and G12 RR/AI 03061. Special thanks to Eric Eisenhardt, Andrew Williams, our participants, and community physicians. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2004/12

Y1 - 2004/12

N2 - There are discrepant findings regarding the risk of HIV-associated dementia (HAD) relating to apolipoprotein E4, suggesting other factors may modulate risk. Furthermore, evidence suggests a changing phenotype of HAD in the era of highly active antiretroviral therapy (HAART), prompting a need to determine if new disease markers have emerged. In this analysis, APOE genotype was determined for 182 participants enrolled in the Hawaii Aging with HIV Cohort. After controlling for age and diabetes status, an independent risk of HAD relating to E4 was seen in older participants [OR=2.898 (1.031-8.244)] but not in younger participants [OR=0.373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART.

AB - There are discrepant findings regarding the risk of HIV-associated dementia (HAD) relating to apolipoprotein E4, suggesting other factors may modulate risk. Furthermore, evidence suggests a changing phenotype of HAD in the era of highly active antiretroviral therapy (HAART), prompting a need to determine if new disease markers have emerged. In this analysis, APOE genotype was determined for 182 participants enrolled in the Hawaii Aging with HIV Cohort. After controlling for age and diabetes status, an independent risk of HAD relating to E4 was seen in older participants [OR=2.898 (1.031-8.244)] but not in younger participants [OR=0.373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART.

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Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii Aging with HIV Cohort

Abstract

Keywords

ASJC Scopus subject areas

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