Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population: The SardiNIA Study

A. Scuteri, S. S. Najjar, M. Orru', G. Albai, J. Strait, K. V. Tarasov, M. G. Piras, A. Cao, D. Schlessinger, M. Uda, E. G. Lakatta

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: We investigated the gender-specific control of cardiovascular (CV) risk factors and subclinical vascular lesions in a founder population in Italy. Methods and Results: 6148 subjects were enrolled (aged 14-102 years) from four towns. Hypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines. A self-reported diagnosis defined awareness of these conditions, and the current use of specific medications as treatment. Prevalence was HT 29.2%, DM 4.8%, LIP 44.1% and was higher in men than in women. Disease prevalence increased with age for every CV risk factor. Men were less likely than women to take anti-HT drugs and to reach BP control (9.9% vs. 16%). Only 17.6% of HT >65 years had a BP ≤140/90 mmHg, though 48.5% were treated. The use of statins was very low (<1/3 of eligible subjects >65 years, those with the highest treatment rate). The ratio of control-to-treated HT was lower in subjects with, than in those without, thicker carotid arteries (31.5% vs. 38.8%, p < 0.05) or stiffer aortas (26.0% vs. 40.0%, p < 0.05) or carotid plaques (26.3% vs. 41.1%, p < 0.05). Conclusion: A large number of subjects at high CV risk are not treated and the management of subclinical vascular lesions is far from optimal.

Original languageEnglish (US)
Pages (from-to)532-541
Number of pages10
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number8
DOIs
StatePublished - Oct 2009
Externally publishedYes

Keywords

  • Control
  • Diabetes
  • Hypercholesterolemia
  • Hypertension
  • Population
  • Subclinical vascular disease
  • Treatment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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