TY - JOUR
T1 - Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population
T2 - The SardiNIA Study
AU - Scuteri, A.
AU - Najjar, S. S.
AU - Orru', M.
AU - Albai, G.
AU - Strait, J.
AU - Tarasov, K. V.
AU - Piras, M. G.
AU - Cao, A.
AU - Schlessinger, D.
AU - Uda, M.
AU - Lakatta, E. G.
N1 - Funding Information:
This work was supported by the Intramural Research Program of the National Institute on Aging (NIA), National Institutes of Health (NIH). The SardiNIA (“ProgeNIA”) team was supported by Contract NO1-AG-1-2109 from the NIA.
PY - 2009/10
Y1 - 2009/10
N2 - Aim: We investigated the gender-specific control of cardiovascular (CV) risk factors and subclinical vascular lesions in a founder population in Italy. Methods and Results: 6148 subjects were enrolled (aged 14-102 years) from four towns. Hypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines. A self-reported diagnosis defined awareness of these conditions, and the current use of specific medications as treatment. Prevalence was HT 29.2%, DM 4.8%, LIP 44.1% and was higher in men than in women. Disease prevalence increased with age for every CV risk factor. Men were less likely than women to take anti-HT drugs and to reach BP control (9.9% vs. 16%). Only 17.6% of HT >65 years had a BP ≤140/90 mmHg, though 48.5% were treated. The use of statins was very low (<1/3 of eligible subjects >65 years, those with the highest treatment rate). The ratio of control-to-treated HT was lower in subjects with, than in those without, thicker carotid arteries (31.5% vs. 38.8%, p < 0.05) or stiffer aortas (26.0% vs. 40.0%, p < 0.05) or carotid plaques (26.3% vs. 41.1%, p < 0.05). Conclusion: A large number of subjects at high CV risk are not treated and the management of subclinical vascular lesions is far from optimal.
AB - Aim: We investigated the gender-specific control of cardiovascular (CV) risk factors and subclinical vascular lesions in a founder population in Italy. Methods and Results: 6148 subjects were enrolled (aged 14-102 years) from four towns. Hypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines. A self-reported diagnosis defined awareness of these conditions, and the current use of specific medications as treatment. Prevalence was HT 29.2%, DM 4.8%, LIP 44.1% and was higher in men than in women. Disease prevalence increased with age for every CV risk factor. Men were less likely than women to take anti-HT drugs and to reach BP control (9.9% vs. 16%). Only 17.6% of HT >65 years had a BP ≤140/90 mmHg, though 48.5% were treated. The use of statins was very low (<1/3 of eligible subjects >65 years, those with the highest treatment rate). The ratio of control-to-treated HT was lower in subjects with, than in those without, thicker carotid arteries (31.5% vs. 38.8%, p < 0.05) or stiffer aortas (26.0% vs. 40.0%, p < 0.05) or carotid plaques (26.3% vs. 41.1%, p < 0.05). Conclusion: A large number of subjects at high CV risk are not treated and the management of subclinical vascular lesions is far from optimal.
KW - Control
KW - Diabetes
KW - Hypercholesterolemia
KW - Hypertension
KW - Population
KW - Subclinical vascular disease
KW - Treatment
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U2 - 10.1016/j.numecd.2008.11.004
DO - 10.1016/j.numecd.2008.11.004
M3 - Article
C2 - 19321325
AN - SCOPUS:67651093563
SN - 0939-4753
VL - 19
SP - 532
EP - 541
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 8
ER -