Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

S. Y. Chang; T. F. Yong; C. Y. Yu; M. C. Liang; O. Pletnikova; J. Troncoso; J. M. Burgunder; T. W. Soong

doi:10.1016/j.neuroscience.2006.12.054

Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

S. Y. Chang, T. F. Yong, C. Y. Yu, M. C. Liang, O. Pletnikova, J. Troncoso, J. M. Burgunder, T. W. Soong

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Ca_v2.1 Ca²⁺ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca²⁺-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.

Original language	English (US)
Pages (from-to)	1026-1036
Number of pages	11
Journal	Neuroscience
Volume	145
Issue number	3
DOIs	https://doi.org/10.1016/j.neuroscience.2006.12.054
State	Published - Mar 30 2007

Keywords

EF hand
aging
calcium channel
developmental switch
mutually-exclusive exons

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuroscience.2006.12.054

Cite this

@article{a2abcbaec78840b2a36587b85bbd29f0,

title = "Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand",

abstract = "Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.",

keywords = "EF hand, aging, calcium channel, developmental switch, mutually-exclusive exons",

author = "Chang, {S. Y.} and Yong, {T. F.} and Yu, {C. Y.} and Liang, {M. C.} and O. Pletnikova and J. Troncoso and Burgunder, {J. M.} and Soong, {T. W.}",

note = "Funding Information: The study was funded by the Biomedical Research Council of Singapore (BMRC grant 01/1/33/18/023). The Brain Resource Center of the Johns Hopkins Medical Institutions is supported by the Johns Hopkins Alzheimer{\textquoteright}s Disease Research Center grant NIA AG 05146. ",

year = "2007",

month = mar,

day = "30",

doi = "10.1016/j.neuroscience.2006.12.054",

language = "English (US)",

volume = "145",

pages = "1026--1036",

journal = "Neuroscience",

issn = "0306-4522",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

AU - Chang, S. Y.

AU - Yong, T. F.

AU - Yu, C. Y.

AU - Liang, M. C.

AU - Pletnikova, O.

AU - Troncoso, J.

AU - Burgunder, J. M.

AU - Soong, T. W.

N1 - Funding Information: The study was funded by the Biomedical Research Council of Singapore (BMRC grant 01/1/33/18/023). The Brain Resource Center of the Johns Hopkins Medical Institutions is supported by the Johns Hopkins Alzheimer’s Disease Research Center grant NIA AG 05146.

PY - 2007/3/30

Y1 - 2007/3/30

N2 - Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.

AB - Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.

KW - EF hand

KW - aging

KW - calcium channel

KW - developmental switch

KW - mutually-exclusive exons

UR - http://www.scopus.com/inward/record.url?scp=33947313013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947313013&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2006.12.054

DO - 10.1016/j.neuroscience.2006.12.054

M3 - Article

C2 - 17291689

AN - SCOPUS:33947313013

SN - 0306-4522

VL - 145

SP - 1026

EP - 1036

JO - Neuroscience

JF - Neuroscience

IS - 3

ER -

Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this