Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

S. Y. Chang, T. F. Yong, C. Y. Yu, M. C. Liang, O. Pletnikova, J. Troncoso, J. M. Burgunder, T. W. Soong

Research output: Contribution to journalArticlepeer-review

Abstract

Cav2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging.

Original languageEnglish (US)
Pages (from-to)1026-1036
Number of pages11
JournalNeuroscience
Volume145
Issue number3
DOIs
StatePublished - Mar 30 2007

Keywords

  • EF hand
  • aging
  • calcium channel
  • developmental switch
  • mutually-exclusive exons

ASJC Scopus subject areas

  • Neuroscience(all)

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