TY - JOUR
T1 - After-discharges and seizures during pediatric extra-operative electrical cortical stimulation functional brain mapping
T2 - Incidence, thresholds, and determinants
AU - Aungaroon, Gewalin
AU - Zea Vera, Alonso
AU - Horn, Paul S.
AU - Byars, Anna W.
AU - Greiner, Hansel M.
AU - Tenney, Jeffrey R.
AU - Arthur, Todd M.
AU - Crone, Nathan E.
AU - Holland, Katherine D.
AU - Mangano, Francesco T.
AU - Arya, Ravindra
N1 - Funding Information:
Disclosures: RA receives research support from Pediatric Epilepsy Research Foundation (Co-I). KDH receives funding from the following NIH grants: R01 NS062756 (PI), R01 NS062806 (Co-I), and R01 NS065020 (Co-I). Other co-authors do not have any pertinent disclosures.
Publisher Copyright:
© 2017 International Federation of Clinical Neurophysiology
PY - 2017/10
Y1 - 2017/10
N2 - Objective This study examined the incidence, thresholds, and determinants of electrical cortical stimulation (ECS)-induced after-discharges (ADs) and seizures. Methods Electrocorticograph recordings were reviewed to determine incidence of ECS-induced ADs and seizures. Multivariable analyses for predictors of AD/seizure occurrence and their thresholds were performed. Results In 122 patients, the incidence of ADs and seizures was 77% (94/122) and 35% (43/122) respectively. Males (odds ratio [OR] 2.92, 95% CI 1.21–7.38, p = 0.02) and MRI-negative patients (OR 3.69, 95% CI 1.24–13.7, p = 0.03) were found to have higher odds of ECS-induced ADs. A significant trend for decreasing AD thresholds with age was seen (regression co-efficient −0.151, 95% CI −0.267 to −0.035, p = 0.011). ECS-induced seizures were more likely in patients with lateralized functional imaging (OR 6.62, 95% CI 1.36–55.56, p = 0.036, for positron emission tomography) and presence of ADs (OR 3.50, 95% CI 1.12–13.36, p = 0.043). Conclusions ECS is associated with a high incidence of ADs and seizures. With age, current thresholds decrease and the probability for AD/seizure occurrence increases. Significance ADs and seizures during ECS brain mapping are potentially hazardous and affect its functional validity. Thus, safer method(s) for brain mapping with improved neurophysiologic validity are desirable.
AB - Objective This study examined the incidence, thresholds, and determinants of electrical cortical stimulation (ECS)-induced after-discharges (ADs) and seizures. Methods Electrocorticograph recordings were reviewed to determine incidence of ECS-induced ADs and seizures. Multivariable analyses for predictors of AD/seizure occurrence and their thresholds were performed. Results In 122 patients, the incidence of ADs and seizures was 77% (94/122) and 35% (43/122) respectively. Males (odds ratio [OR] 2.92, 95% CI 1.21–7.38, p = 0.02) and MRI-negative patients (OR 3.69, 95% CI 1.24–13.7, p = 0.03) were found to have higher odds of ECS-induced ADs. A significant trend for decreasing AD thresholds with age was seen (regression co-efficient −0.151, 95% CI −0.267 to −0.035, p = 0.011). ECS-induced seizures were more likely in patients with lateralized functional imaging (OR 6.62, 95% CI 1.36–55.56, p = 0.036, for positron emission tomography) and presence of ADs (OR 3.50, 95% CI 1.12–13.36, p = 0.043). Conclusions ECS is associated with a high incidence of ADs and seizures. With age, current thresholds decrease and the probability for AD/seizure occurrence increases. Significance ADs and seizures during ECS brain mapping are potentially hazardous and affect its functional validity. Thus, safer method(s) for brain mapping with improved neurophysiologic validity are desirable.
KW - Cortical stimulation mapping
KW - Current thresholds
KW - Epilepsy surgery
KW - Functional brain mapping
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U2 - 10.1016/j.clinph.2017.06.259
DO - 10.1016/j.clinph.2017.06.259
M3 - Article
C2 - 28778475
AN - SCOPUS:85026542579
SN - 1388-2457
VL - 128
SP - 2078
EP - 2086
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 10
ER -