African ancestry is associated with asthma risk in African Americans

Carlos Flores, Shwu Fan Ma, María Pino-Yanes, Michael S. Wade, Lina Pérez-Méndez, Rick A. Kittles, Deli Wang, Srinivas Papaiahgari, Jean G. Ford, Rajesh Kumar, Joe G N Garcia

Research output: Contribution to journalArticle

Abstract

Background: Asthma is a common complex condition with clear racial and ethnic differences in both prevalence and severity. Asthma consultation rates, mortality, and severe symptoms are greatly increased in African descent populations of developed countries. African ancestry has been associated with asthma, total serum IgE and lower pulmonary function in African-admixed populations. To replicate previous findings, here we aimed to examine whether African ancestry was associated with asthma susceptibility in African Americans. In addition, we examined for the first time whether African ancestry was associated with asthma exacerbations. Methodology/Principal Findings: After filtering for self-reported ancestry and genotype data quality, samples from 1,117 self-reported African-American individuals from New York and Baltimore (394 cases, 481 controls), and Chicago (321 cases followed for asthma exacerbations) were analyzed. Genetic ancestry was estimated based on ancestry informative markers (AIMs) selected for being highly divergent among European and West African populations (95 AIMs for New York and Baltimore, and 66 independent AIMs for Chicago). Among case-control samples, the mean African ancestry was significantly higher in asthmatics than in non-asthmatics (82.0±14.0% vs. 77.8±18.1%, mean difference 4.2% [95% confidence interval (CI):2.0-6.4], p

Original languageEnglish (US)
Article numbere26807
JournalPLoS One
Volume7
Issue number1
DOIs
StatePublished - Jan 3 2012

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asthma
African Americans
ancestry
Asthma
Immunoglobulin E
Baltimore
Population
Developed Countries
ethnic differences
Referral and Consultation
lung function
Genotype
Confidence Intervals
developed countries
Lung
signs and symptoms (animals and humans)
Mortality
confidence interval
Serum
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Flores, C., Ma, S. F., Pino-Yanes, M., Wade, M. S., Pérez-Méndez, L., Kittles, R. A., ... Garcia, J. G. N. (2012). African ancestry is associated with asthma risk in African Americans. PLoS One, 7(1), [e26807]. https://doi.org/10.1371/journal.pone.0026807

African ancestry is associated with asthma risk in African Americans. / Flores, Carlos; Ma, Shwu Fan; Pino-Yanes, María; Wade, Michael S.; Pérez-Méndez, Lina; Kittles, Rick A.; Wang, Deli; Papaiahgari, Srinivas; Ford, Jean G.; Kumar, Rajesh; Garcia, Joe G N.

In: PLoS One, Vol. 7, No. 1, e26807, 03.01.2012.

Research output: Contribution to journalArticle

Flores, C, Ma, SF, Pino-Yanes, M, Wade, MS, Pérez-Méndez, L, Kittles, RA, Wang, D, Papaiahgari, S, Ford, JG, Kumar, R & Garcia, JGN 2012, 'African ancestry is associated with asthma risk in African Americans', PLoS One, vol. 7, no. 1, e26807. https://doi.org/10.1371/journal.pone.0026807
Flores C, Ma SF, Pino-Yanes M, Wade MS, Pérez-Méndez L, Kittles RA et al. African ancestry is associated with asthma risk in African Americans. PLoS One. 2012 Jan 3;7(1). e26807. https://doi.org/10.1371/journal.pone.0026807
Flores, Carlos ; Ma, Shwu Fan ; Pino-Yanes, María ; Wade, Michael S. ; Pérez-Méndez, Lina ; Kittles, Rick A. ; Wang, Deli ; Papaiahgari, Srinivas ; Ford, Jean G. ; Kumar, Rajesh ; Garcia, Joe G N. / African ancestry is associated with asthma risk in African Americans. In: PLoS One. 2012 ; Vol. 7, No. 1.
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