TY - JOUR
T1 - African-American heredity prostate cancer study
T2 - A model for genetic research
AU - Powell, Issac J.
AU - Carpten, John
AU - Dunston, Georgia
AU - Kittles, Rick
AU - Bennett, James
AU - Hoke, G.
AU - Pettaway, Curtis
AU - Weinrich, Sally
AU - Vijayakumar, Srinivasan
AU - Ahaghotu, Chiledum A.
AU - Boykin, William
AU - Mason, Terry
AU - Royal, Charmaine
AU - Baffoe-Bonnie, Agnes
AU - Bailey-Wilson, John
AU - Berg, Kate
AU - Trent, Jeffrey
AU - Collins, Francis
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 2001/4
Y1 - 2001/4
N2 - A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.
AB - A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.
KW - Ethnicity
KW - Genetics
KW - Human genome project
KW - Oncology
KW - Prostate cancer
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M3 - Article
C2 - 12653398
AN - SCOPUS:0035531437
SN - 0027-9684
VL - 93
SP - 120
EP - 123
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
IS - 4
ER -