Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease

Research output: Contribution to journalReview articlepeer-review

Abstract

Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough reflex. These vagal afferent nerves may interact centrally with sensory input arising from afferent nerves innervating the intrapulmonary airways or even extrapulmonary afferents such as those innervating the nasal mucosa and esophagus to produce chronic cough or enhanced cough responsiveness. The mechanisms of cough initiation in health and in disease are briefly described.

Original languageEnglish (US)
Pages (from-to)15-25
Number of pages11
JournalOtolaryngologic Clinics of North America
Volume43
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • Bradykinin
  • Capsaicin
  • N-Methyl-d-Aspartate
  • Vagal

ASJC Scopus subject areas

  • Otorhinolaryngology

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