Affective neuroscience strategies for understanding and treating depression: From preclinical models to three novel therapeutics

Jaak Panksepp, Jason S. Wright, Máté D. Döbrössy, Thomas E. Schlaepfer, Volker A. Coenen

Research output: Contribution to journalArticle

Abstract

Mammalian brains contain seven primary-process affective substrates for primal emotional feelings and behaviors. Scientific labels for these interactive systems are SEEKING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY. Understanding these brain substrates could lead to new treatments of emotional disturbances that accompany mental illnesses. We summarize how understanding of such emotional affects—especially those of separation distress (PANIC, promoting excessive sadness and grief), SEEKING (promoting enthusiasm), and PLAY (promoting social joy)—may regulate depressive affect through a focus on the following: (a) reducing PANIC, namely, “psychic pain” with “safe opioids” such as buprenorphine; (b) facilitating enthusiasm with deep brain stimulation of the transdiencephalic medial forebrain bundle–based SEEKING urges; and (c) how studies of brain neurochemical pathways that facilitate social joy (PLAY) in animals have yielded novel neurochemical interventions (e.g., GLYX-13, a partial agonist of glycine receptors) currently in successful human testing. Affective neuroscience principles that have led to these advances are summarized.

Original languageEnglish (US)
Pages (from-to)472-494
Number of pages23
JournalClinical Psychological Science
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2014

Keywords

  • Anterior cingulate area
  • Deep brain stimulation
  • Depression
  • GLYX-13
  • Medial forebrain bundle
  • PANIC system
  • PLAY system
  • Preclinical models
  • SEEKING system

ASJC Scopus subject areas

  • Clinical Psychology

Fingerprint Dive into the research topics of 'Affective neuroscience strategies for understanding and treating depression: From preclinical models to three novel therapeutics'. Together they form a unique fingerprint.

  • Cite this