TY - JOUR
T1 - Affective neuroscience strategies for understanding and treating depression
T2 - From preclinical models to three novel therapeutics
AU - Panksepp, Jaak
AU - Wright, Jason S.
AU - Döbrössy, Máté D.
AU - Schlaepfer, Thomas E.
AU - Coenen, Volker A.
N1 - Funding Information:
V. A. Coenen has received honorariums and travel support from Medtronic Inc. (Europe, United States). T. E. Schlaepfer is a member of the project group Deep Brain Stimulation in Psychiatry: Guidance for Responsible Research and Application, which is funded by the Volkswagen Foundation (Hannover, Germany) and has received limited funding from Medtronic Inc. for an investigator-initiated study on the effects of DBS in major depression (from 2004–2007).
Funding Information:
Research summarized in this article was supported by grants from the Hope for Depression Research Foundation (HDRF) to V. A. Coenen and J. Panksepp, and the Neuropsychoanalytic Research Foundation to J. Panksepp. V. A. Coenen has received limited funding for DBS trials from Medtronic.
Publisher Copyright:
© The Author(s) 2014.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Mammalian brains contain seven primary-process affective substrates for primal emotional feelings and behaviors. Scientific labels for these interactive systems are SEEKING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY. Understanding these brain substrates could lead to new treatments of emotional disturbances that accompany mental illnesses. We summarize how understanding of such emotional affects—especially those of separation distress (PANIC, promoting excessive sadness and grief), SEEKING (promoting enthusiasm), and PLAY (promoting social joy)—may regulate depressive affect through a focus on the following: (a) reducing PANIC, namely, “psychic pain” with “safe opioids” such as buprenorphine; (b) facilitating enthusiasm with deep brain stimulation of the transdiencephalic medial forebrain bundle–based SEEKING urges; and (c) how studies of brain neurochemical pathways that facilitate social joy (PLAY) in animals have yielded novel neurochemical interventions (e.g., GLYX-13, a partial agonist of glycine receptors) currently in successful human testing. Affective neuroscience principles that have led to these advances are summarized.
AB - Mammalian brains contain seven primary-process affective substrates for primal emotional feelings and behaviors. Scientific labels for these interactive systems are SEEKING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY. Understanding these brain substrates could lead to new treatments of emotional disturbances that accompany mental illnesses. We summarize how understanding of such emotional affects—especially those of separation distress (PANIC, promoting excessive sadness and grief), SEEKING (promoting enthusiasm), and PLAY (promoting social joy)—may regulate depressive affect through a focus on the following: (a) reducing PANIC, namely, “psychic pain” with “safe opioids” such as buprenorphine; (b) facilitating enthusiasm with deep brain stimulation of the transdiencephalic medial forebrain bundle–based SEEKING urges; and (c) how studies of brain neurochemical pathways that facilitate social joy (PLAY) in animals have yielded novel neurochemical interventions (e.g., GLYX-13, a partial agonist of glycine receptors) currently in successful human testing. Affective neuroscience principles that have led to these advances are summarized.
KW - Anterior cingulate area
KW - Deep brain stimulation
KW - Depression
KW - GLYX-13
KW - Medial forebrain bundle
KW - PANIC system
KW - PLAY system
KW - Preclinical models
KW - SEEKING system
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U2 - 10.1177/2167702614535913
DO - 10.1177/2167702614535913
M3 - Article
AN - SCOPUS:84925448260
VL - 2
SP - 472
EP - 494
JO - Clinical Psychological Science
JF - Clinical Psychological Science
SN - 2167-7026
IS - 4
ER -