Aerosolized gentamicin reduces the burden of tuberculosis in a murine model

Chad J. Roy; Satheesh K. Sivasubramani; Noton K. Dutta; Smriti Mehra; Nadia A. Golden; Stephanie Killeen; James D. Talton; Badre E. Hammoud; Peter J. Didier; Deepak Kaushal

doi:10.1128/AAC.05633-11

Aerosolized gentamicin reduces the burden of tuberculosis in a murine model

Chad J. Roy, Satheesh K. Sivasubramani, Noton K. Dutta, Smriti Mehra, Nadia A. Golden, Stephanie Killeen, James D. Talton, Badre E. Hammoud, Peter J. Didier, Deepak Kaushal

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Tuberculosis (TB) is a major infectious disease problem: 1.7 million people annually die due to TB. Emergence of drug-resistant Mycobacterium tuberculosis and the lack of new antibiotics have exacerbated the situation. There is an urgent need to develop or repurpose drugs against TB. We evaluated inhaled gentamicin as direct respiratory system-targeted therapy in a murine model of TB. Aerosolized-gentamicin-treated mice showed significantly reduced lung M. tuberculosis loads and fewer granulomas relative to untreated controls. These results suggest that direct delivery of antibiotics to the respiratory system may provide therapeutic benefit to conventional treatment regimes for treatment of pulmonary TB.

Original language	English (US)
Pages (from-to)	883-886
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	2
DOIs	https://doi.org/10.1128/AAC.05633-11
State	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Tuberculosis (TB) is a major infectious disease problem: 1.7 million people annually die due to TB. Emergence of drug-resistant Mycobacterium tuberculosis and the lack of new antibiotics have exacerbated the situation. There is an urgent need to develop or repurpose drugs against TB. We evaluated inhaled gentamicin as direct respiratory system-targeted therapy in a murine model of TB. Aerosolized-gentamicin-treated mice showed significantly reduced lung M. tuberculosis loads and fewer granulomas relative to untreated controls. These results suggest that direct delivery of antibiotics to the respiratory system may provide therapeutic benefit to conventional treatment regimes for treatment of pulmonary TB.",

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AU - Roy, Chad J.

AU - Sivasubramani, Satheesh K.

AU - Dutta, Noton K.

AU - Mehra, Smriti

AU - Golden, Nadia A.

AU - Killeen, Stephanie

AU - Talton, James D.

AU - Hammoud, Badre E.

AU - Didier, Peter J.

AU - Kaushal, Deepak

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Aerosolized gentamicin reduces the burden of tuberculosis in a murine model

Abstract

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