The antibody response was compared in 40 volunteers who were immunized with parainfluenza Type 2 vaccine, either subcutaneously or by aerosol, and in 16 controls. The neutralizing-antibody response in respiratory secretions was of greater magnitude in the aerosol group than in the other groups. In both the aerosol and the subcutaneous groups there was a significant rise in serum antibody. The respiratory-secretion antibody was found in the IgA class.
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