Aerosol clearance by the bronchial circulation

Elizabeth M. Wagner

doi:10.1089/jam.1996.9.7

Aerosol clearance by the bronchial circulation

Elizabeth M. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The importance of the tracheobronchial circulation in supporting mucociliary clearance is unclear. In anesthetized, ventilated sheep (n = 8), mucociliary transport of ^99mTc-labeled sulfur colloid particles (2.1 μm) was measured during control perfusion of the cannulated bronchial branch of the bronchoesophageal artery or when perfusion through this artery was stopped. Particle retention 60 min after aerosol delivery of particles averaged 55% during control bronchial blood flow conditions. When perfusion was stopped, average retention was significantly increased to 76% (p < 0.05). These results indicate that the bronchial vasculature exerts an important modulating influence on mucociliary transport.

Original language	English (US)
Pages (from-to)	7-10
Number of pages	4
Journal	Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Volume	9
Issue number	1
DOIs	https://doi.org/10.1089/jam.1996.9.7
State	Published - Jan 1 1996

Keywords

bronchial blood flow
mucociliary transport
sheep
sheep

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Pharmacology (medical)

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10.1089/jam.1996.9.7

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AB - The importance of the tracheobronchial circulation in supporting mucociliary clearance is unclear. In anesthetized, ventilated sheep (n = 8), mucociliary transport of 99mTc-labeled sulfur colloid particles (2.1 μm) was measured during control perfusion of the cannulated bronchial branch of the bronchoesophageal artery or when perfusion through this artery was stopped. Particle retention 60 min after aerosol delivery of particles averaged 55% during control bronchial blood flow conditions. When perfusion was stopped, average retention was significantly increased to 76% (p < 0.05). These results indicate that the bronchial vasculature exerts an important modulating influence on mucociliary transport.

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Aerosol clearance by the bronchial circulation

Abstract

Keywords

ASJC Scopus subject areas

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