Aerosol clearance by the bronchial circulation

Research output: Contribution to journalArticle

Abstract

The importance of the tracheobronchial circulation in supporting mucociliary clearance is unclear. In anesthetized, ventilated sheep (n = 8), mucociliary transport of 99mTc-labeled sulfur colloid particles (2.1 μm) was measured during control perfusion of the cannulated bronchial branch of the bronchoesophageal artery or when perfusion through this artery was stopped. Particle retention 60 min after aerosol delivery of particles averaged 55% during control bronchial blood flow conditions. When perfusion was stopped, average retention was significantly increased to 76% (p < 0.05). These results indicate that the bronchial vasculature exerts an important modulating influence on mucociliary transport.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1996

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Keywords

  • bronchial blood flow
  • mucociliary transport
  • sheep
  • sheep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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