Aerobic exercise modulates the free fatty acids and inflammatory response during obesity and cancer cachexia

Alexandre Abilio de S. Teixeira, Fábio S. Lira, Gustavo D. Pimentel, Camila Oliveira de Souza, Helena Batatinha, Luana A. Biondo, Alex S. Yamashita, Edson A. Lima Júnior, José C. Rosa Neto

Research output: Contribution to journalArticlepeer-review

Abstract

White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.

Original languageEnglish (US)
Pages (from-to)187-198
Number of pages12
JournalCritical Reviews in Eukaryotic Gene Expression
Volume26
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Aerobic exercise
  • Cancer cachexia
  • Inflammation
  • Obesity
  • White adipose tissue

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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