Adverse oral health and cognitive decline

The health, aging and body composition study

Robert Stewart, Robert J. Weyant, Melissa E. Garcia, Tamara Harris, Lenore J. Launer, Suzanne Satterfield, Eleanor Marie Simonsick, Kristine Yaffe, Anne B. Newman

Research output: Contribution to journalArticle

Abstract

Objectives To investigate the relationship between periodontal disease and cognitive decline. Design Analysis of a prospective cohort study. Setting The Health, Aging and Body Composition (Health ABC) Study. Participants One thousand fifty-three participants who were administered the Modified Mini-Mental State Examination (3MS) at Year 1 (baseline) and Year 3 and had participated in a comprehensive periodontal examination at Year 2. Measurements The prospective association between a range of oral health parameters and cognitive function was examined. Decline in 3MS score from Year 3 to 5 was investigated in 947 (89.9%) participants. Covariates included age, sex, education, race, cardiovascular disease and risk, and depressive symptoms. Results Most indicators of adverse oral health at Year 2 were associated with cognitive impairment based on averaged 3MS scores less than 80 for Years 1 and 3, but education and race substantially confounded these associations. Higher gingival index, a measure of gingival inflammation, at Year 2 remained independently associated with this definition of cognitive impairment and, in fully adjusted analyses, was also an independent predictor of a more-than-5-point cognitive decline from Year 3 to 5. Conclusion Periodontitis may be a risk factor for cognitive decline. Gingivitis is reversible, and periodontitis to some degree is preventable and controllable when manifest. Therefore, further research is needed to clarify potential underlying mechanisms and oral health interventions that might ameliorate cognitive decline.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalJournal of the American Geriatrics Society
Volume61
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Oral Health
Body Composition
Health
Periodontitis
Periodontal Index
Gingivitis
Sex Education
Periodontal Diseases
Cognition
Cognitive Dysfunction
Cohort Studies
Cardiovascular Diseases
Prospective Studies
Depression
Inflammation
Education
Research

Keywords

  • cognitive decline
  • cognitive impairment
  • gingivitis
  • periodontal disease
  • periodontitis

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Stewart, R., Weyant, R. J., Garcia, M. E., Harris, T., Launer, L. J., Satterfield, S., ... Newman, A. B. (2013). Adverse oral health and cognitive decline: The health, aging and body composition study. Journal of the American Geriatrics Society, 61(2), 177-184. https://doi.org/10.1111/jgs.12094

Adverse oral health and cognitive decline : The health, aging and body composition study. / Stewart, Robert; Weyant, Robert J.; Garcia, Melissa E.; Harris, Tamara; Launer, Lenore J.; Satterfield, Suzanne; Simonsick, Eleanor Marie; Yaffe, Kristine; Newman, Anne B.

In: Journal of the American Geriatrics Society, Vol. 61, No. 2, 02.2013, p. 177-184.

Research output: Contribution to journalArticle

Stewart, R, Weyant, RJ, Garcia, ME, Harris, T, Launer, LJ, Satterfield, S, Simonsick, EM, Yaffe, K & Newman, AB 2013, 'Adverse oral health and cognitive decline: The health, aging and body composition study', Journal of the American Geriatrics Society, vol. 61, no. 2, pp. 177-184. https://doi.org/10.1111/jgs.12094
Stewart, Robert ; Weyant, Robert J. ; Garcia, Melissa E. ; Harris, Tamara ; Launer, Lenore J. ; Satterfield, Suzanne ; Simonsick, Eleanor Marie ; Yaffe, Kristine ; Newman, Anne B. / Adverse oral health and cognitive decline : The health, aging and body composition study. In: Journal of the American Geriatrics Society. 2013 ; Vol. 61, No. 2. pp. 177-184.
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