Abstract
Purpose: Recent research has enhanced our understanding of radiation injury at the molecular-cellular and tissue levels; significant strides have occurred in standardization of adverse event reporting in clinical trials. In response, the International Atomic Energy Agency, through its Division of Human Health and its section for Applied Radiation Biology and Radiotherapy, organized a consultation meeting in Atlanta (October 2, 2004) to discuss developments in radiobiology, normal tissue reactions, and adverse event reporting. Methods and Materials: Representatives from cooperative groups of African Radiation Oncology Group, Curriculo Radioterapeutica Ibero Latino Americana, European Organization for Research and Treatment of Cancer, National Cancer Institute of Canada Clinical Trials Group, Radiation Therapy Oncology Group, and Trans-Tasman Radiation Oncology Group held the meeting discussion. Results: Representatives of major radiotherapy groups/organizations and prominent leaders in radiotherapy discussed current understanding of normal tissue radiobiologic effects, the design and implementation of future clinical and translational projects for normal tissue injury, and the standardization of adverse-event reporting worldwide. Conclusions: The consensus was to adopt NCI comprehensive adverse event reporting terminology and grading system (CTCAE v3.0) as the new standard for all cooperative group trials. Future plans included the implementation of coordinated research projects focusing on normal tissue biomarkers and data collection methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1442-1451 |
| Number of pages | 10 |
| Journal | International Journal of Radiation Oncology, Biology, Physics |
| Volume | 64 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 1 2006 |
| Externally published | Yes |
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Keywords
- Biomarkers
- Common toxicity criteria
- IAEA
- Late effects
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
Adverse event reporting and developments in radiation biology after normal tissue injury : International Atomic Energy Agency consultation. / Chen, Yuhchyau; Trotti, Andy; Coleman, C. Norman; MacHtay, Mitchell; Mirimanoff, Rene O.; Hay, John; O'Brien, Peter C.; El-Gueddari, Brahim; Salvajoli, Joao V.; Jeremic, Branislav.
In: International Journal of Radiation Oncology, Biology, Physics, Vol. 64, No. 5, 01.04.2006, p. 1442-1451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adverse event reporting and developments in radiation biology after normal tissue injury
T2 - International Atomic Energy Agency consultation
AU - Chen, Yuhchyau
AU - Trotti, Andy
AU - Coleman, C. Norman
AU - MacHtay, Mitchell
AU - Mirimanoff, Rene O.
AU - Hay, John
AU - O'Brien, Peter C.
AU - El-Gueddari, Brahim
AU - Salvajoli, Joao V.
AU - Jeremic, Branislav
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Purpose: Recent research has enhanced our understanding of radiation injury at the molecular-cellular and tissue levels; significant strides have occurred in standardization of adverse event reporting in clinical trials. In response, the International Atomic Energy Agency, through its Division of Human Health and its section for Applied Radiation Biology and Radiotherapy, organized a consultation meeting in Atlanta (October 2, 2004) to discuss developments in radiobiology, normal tissue reactions, and adverse event reporting. Methods and Materials: Representatives from cooperative groups of African Radiation Oncology Group, Curriculo Radioterapeutica Ibero Latino Americana, European Organization for Research and Treatment of Cancer, National Cancer Institute of Canada Clinical Trials Group, Radiation Therapy Oncology Group, and Trans-Tasman Radiation Oncology Group held the meeting discussion. Results: Representatives of major radiotherapy groups/organizations and prominent leaders in radiotherapy discussed current understanding of normal tissue radiobiologic effects, the design and implementation of future clinical and translational projects for normal tissue injury, and the standardization of adverse-event reporting worldwide. Conclusions: The consensus was to adopt NCI comprehensive adverse event reporting terminology and grading system (CTCAE v3.0) as the new standard for all cooperative group trials. Future plans included the implementation of coordinated research projects focusing on normal tissue biomarkers and data collection methods.
AB - Purpose: Recent research has enhanced our understanding of radiation injury at the molecular-cellular and tissue levels; significant strides have occurred in standardization of adverse event reporting in clinical trials. In response, the International Atomic Energy Agency, through its Division of Human Health and its section for Applied Radiation Biology and Radiotherapy, organized a consultation meeting in Atlanta (October 2, 2004) to discuss developments in radiobiology, normal tissue reactions, and adverse event reporting. Methods and Materials: Representatives from cooperative groups of African Radiation Oncology Group, Curriculo Radioterapeutica Ibero Latino Americana, European Organization for Research and Treatment of Cancer, National Cancer Institute of Canada Clinical Trials Group, Radiation Therapy Oncology Group, and Trans-Tasman Radiation Oncology Group held the meeting discussion. Results: Representatives of major radiotherapy groups/organizations and prominent leaders in radiotherapy discussed current understanding of normal tissue radiobiologic effects, the design and implementation of future clinical and translational projects for normal tissue injury, and the standardization of adverse-event reporting worldwide. Conclusions: The consensus was to adopt NCI comprehensive adverse event reporting terminology and grading system (CTCAE v3.0) as the new standard for all cooperative group trials. Future plans included the implementation of coordinated research projects focusing on normal tissue biomarkers and data collection methods.
KW - Biomarkers
KW - Common toxicity criteria
KW - IAEA
KW - Late effects
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=33645359996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645359996&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2005.10.014
DO - 10.1016/j.ijrobp.2005.10.014
M3 - Article
C2 - 16414207
AN - SCOPUS:33645359996
VL - 64
SP - 1442
EP - 1451
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
SN - 0360-3016
IS - 5
ER -