Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation

Yuhchyau Chen, Andy Trotti, C. Norman Coleman, Mitchell MacHtay, Rene O. Mirimanoff, John Hay, Peter C. O'Brien, Brahim El-Gueddari, Joao V. Salvajoli, Branislav Jeremic

Research output: Contribution to journalArticle

Abstract

Purpose: Recent research has enhanced our understanding of radiation injury at the molecular-cellular and tissue levels; significant strides have occurred in standardization of adverse event reporting in clinical trials. In response, the International Atomic Energy Agency, through its Division of Human Health and its section for Applied Radiation Biology and Radiotherapy, organized a consultation meeting in Atlanta (October 2, 2004) to discuss developments in radiobiology, normal tissue reactions, and adverse event reporting. Methods and Materials: Representatives from cooperative groups of African Radiation Oncology Group, Curriculo Radioterapeutica Ibero Latino Americana, European Organization for Research and Treatment of Cancer, National Cancer Institute of Canada Clinical Trials Group, Radiation Therapy Oncology Group, and Trans-Tasman Radiation Oncology Group held the meeting discussion. Results: Representatives of major radiotherapy groups/organizations and prominent leaders in radiotherapy discussed current understanding of normal tissue radiobiologic effects, the design and implementation of future clinical and translational projects for normal tissue injury, and the standardization of adverse-event reporting worldwide. Conclusions: The consensus was to adopt NCI comprehensive adverse event reporting terminology and grading system (CTCAE v3.0) as the new standard for all cooperative group trials. Future plans included the implementation of coordinated research projects focusing on normal tissue biomarkers and data collection methods.

Original languageEnglish (US)
Pages (from-to)1442-1451
Number of pages10
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume64
Issue number5
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Radiobiology
Nuclear Energy
nuclear energy
biology
Referral and Consultation
Radiation Oncology
Radiotherapy
Wounds and Injuries
radiation
radiation therapy
standardization
Research
Clinical Trials
Organizations
Radiation Injuries
Group Processes
National Cancer Institute (U.S.)
Atlanta (GA)
cancer
Group Psychotherapy

Keywords

  • Biomarkers
  • Common toxicity criteria
  • IAEA
  • Late effects
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Adverse event reporting and developments in radiation biology after normal tissue injury : International Atomic Energy Agency consultation. / Chen, Yuhchyau; Trotti, Andy; Coleman, C. Norman; MacHtay, Mitchell; Mirimanoff, Rene O.; Hay, John; O'Brien, Peter C.; El-Gueddari, Brahim; Salvajoli, Joao V.; Jeremic, Branislav.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 64, No. 5, 01.04.2006, p. 1442-1451.

Research output: Contribution to journalArticle

Chen, Y, Trotti, A, Coleman, CN, MacHtay, M, Mirimanoff, RO, Hay, J, O'Brien, PC, El-Gueddari, B, Salvajoli, JV & Jeremic, B 2006, 'Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation', International Journal of Radiation Oncology, Biology, Physics, vol. 64, no. 5, pp. 1442-1451. https://doi.org/10.1016/j.ijrobp.2005.10.014
Chen, Yuhchyau ; Trotti, Andy ; Coleman, C. Norman ; MacHtay, Mitchell ; Mirimanoff, Rene O. ; Hay, John ; O'Brien, Peter C. ; El-Gueddari, Brahim ; Salvajoli, Joao V. ; Jeremic, Branislav. / Adverse event reporting and developments in radiation biology after normal tissue injury : International Atomic Energy Agency consultation. In: International Journal of Radiation Oncology, Biology, Physics. 2006 ; Vol. 64, No. 5. pp. 1442-1451.
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