Adverse effect of a cigarette smoke component, acrolein, on pulmonary antibacterial defenses and on viral bacterial interactions in the lung

G. J. Jakab

Research output: Contribution to journalArticle

Abstract

Intrapulmonary antibacterial activity in normal mice and mice with viral pneumonia was determined after continuous exposure to the pure tobacco smoke component, acrolein. After inhalation challenge with Staphylococcus aureus and Proteus mirabilis, exposure to 1 to 2 ppm of acrolein significantly suppressed the intrapulmonary killing of the organisms in normal mice compared to control mice not exposed to acrolein. Sendai virus pneumonia depressed pulmonary antibacterial defenses in a virus dose related fashion. Exposure of the mice infected with virus to acrolein resulted in a further suppression of intrapulmonary bacterial killing to the extent that, in most instances, the bacteria proliferated in the lungs. These data demonstrate that the cigarette smoke component, acrolein, not only depresses pulmonary bactericidal activity, but can also act as a stressor in aggravating an underlying disease process, resulting in an additional impairment of pulmonary antibacterial defenses.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume115
Issue number1
StatePublished - 1977
Externally publishedYes

Fingerprint

Acrolein
Smoke
Tobacco Products
Lung
Viral Pneumonia
Viruses
Sendai virus
Proteus mirabilis
Inhalation
Tobacco
Staphylococcus aureus
Pneumonia
Bacteria

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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