TY - JOUR
T1 - Adverse childhood experiences (ACEs) and transitions in stages of alcohol involvement among US adults
T2 - Progression and regression
AU - Alvanzo, Anika A.H.
AU - Storr, Carla L.
AU - Reboussin, Beth
AU - Green, Kerry M.
AU - Mojtabai, Ramin
AU - La Flair, Lareina N.
AU - Cullen, Bernadette A.
AU - Susukida, Ryoko
AU - Seamans, Marissa
AU - Crum, Rosa M.
N1 - Funding Information:
The analyses and preparation of this project were supported by grants from the National Institute on Alcohol Abuse and Alcoholism ( AA016346 ), and the National Institute on Drug Abuse ( DA030460 ) and ( T32DA007292 ). The NIAAA and NIDA had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
Funding Information:
Dr. Mojtabai has received consulting fees and research funding from Bristol-Myers Squibb and Ludbeck pharmaceuticals in the past. All other authors declare that they have no conflicts of interest.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/9
Y1 - 2020/9
N2 - Background: Adverse childhood experiences (ACEs) are associated with a number of medical comorbidities. However, there is a paucity of data on the role ACEs play in transitions in stages of alcohol involvement. Objective: To examine the association between ACEs and transitions in alcohol problems progression and regression between No Problems, Moderate Problems and Severe Problems stages. Participants and setting: Data from 14,363 male and 19,774 female participants in Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Methods: We used latent transition analysis (LTA) with propensity score adjustment to estimate the odds of transitioning across stages of alcohol involvement, between waves, based on the number of types of ACEs experienced. We hypothesized that ACEs would be associated with increased risk of progression and decreased risk of regression. Results: ACEs were associated with progression to higher alcohol involvement stages, with greatest likelihood of progression from No Problems to Severe Problems for those reporting ≥3 ACEs (males: aOR = 4.78 [CI (1.84–12.44)]; females: aOR = 3.81 [CI (1.69–8.57)]). ACEs were also associated with decreased odds of regression to less problematic alcohol involvement stages, with some distinctive patterns of associations in males and in females. Conclusions: This study suggests that ACEs impact transitions in alcohol involvement in both males and females, affecting both progression and regression. The association is magnified for those with multiple types of ACE exposures. These results highlight the need for prevention, early identification and intervention to mitigate the risks associated with childhood maltreatment.
AB - Background: Adverse childhood experiences (ACEs) are associated with a number of medical comorbidities. However, there is a paucity of data on the role ACEs play in transitions in stages of alcohol involvement. Objective: To examine the association between ACEs and transitions in alcohol problems progression and regression between No Problems, Moderate Problems and Severe Problems stages. Participants and setting: Data from 14,363 male and 19,774 female participants in Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Methods: We used latent transition analysis (LTA) with propensity score adjustment to estimate the odds of transitioning across stages of alcohol involvement, between waves, based on the number of types of ACEs experienced. We hypothesized that ACEs would be associated with increased risk of progression and decreased risk of regression. Results: ACEs were associated with progression to higher alcohol involvement stages, with greatest likelihood of progression from No Problems to Severe Problems for those reporting ≥3 ACEs (males: aOR = 4.78 [CI (1.84–12.44)]; females: aOR = 3.81 [CI (1.69–8.57)]). ACEs were also associated with decreased odds of regression to less problematic alcohol involvement stages, with some distinctive patterns of associations in males and in females. Conclusions: This study suggests that ACEs impact transitions in alcohol involvement in both males and females, affecting both progression and regression. The association is magnified for those with multiple types of ACE exposures. These results highlight the need for prevention, early identification and intervention to mitigate the risks associated with childhood maltreatment.
KW - Adverse childhood experiences
KW - Alcohol
KW - Childhood maltreatment
KW - Latent class analysis
KW - Latent transition analysis
UR - http://www.scopus.com/inward/record.url?scp=85087986495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087986495&partnerID=8YFLogxK
U2 - 10.1016/j.chiabu.2020.104624
DO - 10.1016/j.chiabu.2020.104624
M3 - Article
C2 - 32683202
AN - SCOPUS:85087986495
SN - 0145-2134
VL - 107
JO - Child Abuse and Neglect
JF - Child Abuse and Neglect
M1 - 104624
ER -