TY - JOUR
T1 - Adventitial lymphocytic inflammation in human coronary arteries with intimal atherosclerosis
AU - Tavora, Fabio
AU - Kutys, Robert
AU - Li, Ling
AU - Ripple, Mary
AU - Fowler, David
AU - Burke, Allen
PY - 2010/5
Y1 - 2010/5
N2 - Background: The relationship between adventitial inflammation, plaque type, and culprit plaque morphology in the epicardial arterial circulation has not been studied in detail. Methods: We studied semiserial sections of coronary arteries at autopsy from patients dying with severe coronary disease, 81 men (age 50±12 years) and 13 women (age 52±13 years). Lesions were classified at 3- to 5-mm segments according to modified AHA criteria. Adventitial lymphocyte aggregates were assessed at every 5-mm interval and graded semiquantitatively. Macrophage density in the adventitial fat and intima was assessed with anti-CD68 staining. Results: Adventitial lymphocytic inflammation increased with percent stenosis (P.2). Hemorrhage into late core, rupture, erosion, and thin caps all had greater adventitial lymphocytic inflammation independent of percent stenosis (P2 vs. 121±15 mm2 in fibrous plaques; P=.02) and correlated positively with adventitial lymphocytes (P
AB - Background: The relationship between adventitial inflammation, plaque type, and culprit plaque morphology in the epicardial arterial circulation has not been studied in detail. Methods: We studied semiserial sections of coronary arteries at autopsy from patients dying with severe coronary disease, 81 men (age 50±12 years) and 13 women (age 52±13 years). Lesions were classified at 3- to 5-mm segments according to modified AHA criteria. Adventitial lymphocyte aggregates were assessed at every 5-mm interval and graded semiquantitatively. Macrophage density in the adventitial fat and intima was assessed with anti-CD68 staining. Results: Adventitial lymphocytic inflammation increased with percent stenosis (P.2). Hemorrhage into late core, rupture, erosion, and thin caps all had greater adventitial lymphocytic inflammation independent of percent stenosis (P2 vs. 121±15 mm2 in fibrous plaques; P=.02) and correlated positively with adventitial lymphocytes (P
KW - Adventitial lymphocytic inflammation
KW - Coronary artery disease
KW - Plaque morphology
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U2 - 10.1016/j.carpath.2009.02.001
DO - 10.1016/j.carpath.2009.02.001
M3 - Article
C2 - 19375947
AN - SCOPUS:77951880438
SN - 1054-8807
VL - 19
JO - Cardiovascular Pathology
JF - Cardiovascular Pathology
IS - 3
ER -