Adventitial lymphocytic inflammation in human coronary arteries with intimal atherosclerosis

Fabio Tavora, Robert Kutys, Ling Li, Mary Ripple, David Fowler, Allen Burke

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The relationship between adventitial inflammation, plaque type, and culprit plaque morphology in the epicardial arterial circulation has not been studied in detail. Methods: We studied semiserial sections of coronary arteries at autopsy from patients dying with severe coronary disease, 81 men (age 50±12 years) and 13 women (age 52±13 years). Lesions were classified at 3- to 5-mm segments according to modified AHA criteria. Adventitial lymphocyte aggregates were assessed at every 5-mm interval and graded semiquantitatively. Macrophage density in the adventitial fat and intima was assessed with anti-CD68 staining. Results: Adventitial lymphocytic inflammation increased with percent stenosis (P.2). Hemorrhage into late core, rupture, erosion, and thin caps all had greater adventitial lymphocytic inflammation independent of percent stenosis (P2 vs. 121±15 mm2 in fibrous plaques; P=.02) and correlated positively with adventitial lymphocytes (P

Original languageEnglish (US)
JournalCardiovascular Pathology
Volume19
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Adventitial lymphocytic inflammation
  • Coronary artery disease
  • Plaque morphology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

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