Advances in the Management of Central Nervous System Infections in the ICU

Wendy C Ziai, John J. Lewin

Research output: Contribution to journalArticle


The management of patients who have CNS infections is challenging. Therapy for CNS infections is evolving in light of changing microbial resistance patterns and with the introduction of new antimicrobial agents. Knowledge of cerebral inflammation, molecular diagnostics, and the evolving microbial epidemiology are important to optimizing therapy in patients with meningitis. Future investigations into the role of selective immunomodulation and other neuroprotective strategies may lead to significant advances in the management of CNS infection.

Original languageEnglish (US)
Pages (from-to)661-694
Number of pages34
JournalCritical Care Clinics
Issue number4
Publication statusPublished - Oct 2006


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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