Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions

Tsui Lien Mao, Ie Ming Shih

Research output: Contribution to journalArticle

Abstract

Background: Gestational trophoblastic tumors and tumor-like lesions are derived from trophoblastic cells and are composed of different trophoblastic subpopulations. Recent histopathological and molecular studies indicate that these trophoblast-related lesions recapitulate the differentiation of normal trophoblast in early placenta development. Objective: To distinguish trophoblastic tumors from other types of neoplastic disease and differential diagnosis among different types of trophoblastic lesion are important as far as treatment plans are concerned. Methods: This article reviews the histopathological features of these trophoblastic lesions and recent advances in the trophoblast-associated markers, which are helpful in differential diagnosis. Results/conclusion: Histopathologic features serve as the basis in the diagnosis of various types of trophoblastic lesion. In difficult cases, a stepwise immunohistochemistry approach, called trophogram, may prove useful in assisting the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)371-380
Number of pages10
JournalExpert Opinion on Medical Diagnostics
Volume3
Issue number4
DOIs
StatePublished - Jul 2009

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Trophoblastic Neoplasms
Trophoblasts
Tumors
Differential Diagnosis
Neoplasms
Placenta
Immunohistochemistry
Therapeutics

Keywords

  • Differential diagnosis
  • Gestational trophoblastic tumor
  • Gynecologic pathology
  • Trophoblastic disease

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)
  • Biochemistry, medical
  • Molecular Medicine

Cite this

Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions. / Mao, Tsui Lien; Shih, Ie Ming.

In: Expert Opinion on Medical Diagnostics, Vol. 3, No. 4, 07.2009, p. 371-380.

Research output: Contribution to journalArticle

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