Abstract
Background: Gestational trophoblastic tumors and tumor-like lesions are derived from trophoblastic cells and are composed of different trophoblastic subpopulations. Recent histopathological and molecular studies indicate that these trophoblast-related lesions recapitulate the differentiation of normal trophoblast in early placenta development. Objective: To distinguish trophoblastic tumors from other types of neoplastic disease and differential diagnosis among different types of trophoblastic lesion are important as far as treatment plans are concerned. Methods: This article reviews the histopathological features of these trophoblastic lesions and recent advances in the trophoblast-associated markers, which are helpful in differential diagnosis. Results/conclusion: Histopathologic features serve as the basis in the diagnosis of various types of trophoblastic lesion. In difficult cases, a stepwise immunohistochemistry approach, called trophogram, may prove useful in assisting the differential diagnosis.
Original language | English (US) |
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Pages (from-to) | 371-380 |
Number of pages | 10 |
Journal | Expert Opinion on Medical Diagnostics |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1 2009 |
Keywords
- Differential diagnosis
- Gestational trophoblastic tumor
- Gynecologic pathology
- Trophoblastic disease
ASJC Scopus subject areas
- Biomedical Engineering
- Molecular Medicine
- Biochemistry, medical