Abstract
Background: Gestational trophoblastic tumors and tumor-like lesions are derived from trophoblastic cells and are composed of different trophoblastic subpopulations. Recent histopathological and molecular studies indicate that these trophoblast-related lesions recapitulate the differentiation of normal trophoblast in early placenta development. Objective: To distinguish trophoblastic tumors from other types of neoplastic disease and differential diagnosis among different types of trophoblastic lesion are important as far as treatment plans are concerned. Methods: This article reviews the histopathological features of these trophoblastic lesions and recent advances in the trophoblast-associated markers, which are helpful in differential diagnosis. Results/conclusion: Histopathologic features serve as the basis in the diagnosis of various types of trophoblastic lesion. In difficult cases, a stepwise immunohistochemistry approach, called trophogram, may prove useful in assisting the differential diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 371-380 |
| Number of pages | 10 |
| Journal | Expert Opinion on Medical Diagnostics |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2009 |
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Keywords
- Differential diagnosis
- Gestational trophoblastic tumor
- Gynecologic pathology
- Trophoblastic disease
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine(all)
- Biochemistry, medical
- Molecular Medicine
Cite this
Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions. / Mao, Tsui Lien; Shih, Ie Ming.
In: Expert Opinion on Medical Diagnostics, Vol. 3, No. 4, 07.2009, p. 371-380.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions
AU - Mao, Tsui Lien
AU - Shih, Ie Ming
PY - 2009/7
Y1 - 2009/7
N2 - Background: Gestational trophoblastic tumors and tumor-like lesions are derived from trophoblastic cells and are composed of different trophoblastic subpopulations. Recent histopathological and molecular studies indicate that these trophoblast-related lesions recapitulate the differentiation of normal trophoblast in early placenta development. Objective: To distinguish trophoblastic tumors from other types of neoplastic disease and differential diagnosis among different types of trophoblastic lesion are important as far as treatment plans are concerned. Methods: This article reviews the histopathological features of these trophoblastic lesions and recent advances in the trophoblast-associated markers, which are helpful in differential diagnosis. Results/conclusion: Histopathologic features serve as the basis in the diagnosis of various types of trophoblastic lesion. In difficult cases, a stepwise immunohistochemistry approach, called trophogram, may prove useful in assisting the differential diagnosis.
AB - Background: Gestational trophoblastic tumors and tumor-like lesions are derived from trophoblastic cells and are composed of different trophoblastic subpopulations. Recent histopathological and molecular studies indicate that these trophoblast-related lesions recapitulate the differentiation of normal trophoblast in early placenta development. Objective: To distinguish trophoblastic tumors from other types of neoplastic disease and differential diagnosis among different types of trophoblastic lesion are important as far as treatment plans are concerned. Methods: This article reviews the histopathological features of these trophoblastic lesions and recent advances in the trophoblast-associated markers, which are helpful in differential diagnosis. Results/conclusion: Histopathologic features serve as the basis in the diagnosis of various types of trophoblastic lesion. In difficult cases, a stepwise immunohistochemistry approach, called trophogram, may prove useful in assisting the differential diagnosis.
KW - Differential diagnosis
KW - Gestational trophoblastic tumor
KW - Gynecologic pathology
KW - Trophoblastic disease
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UR - http://www.scopus.com/inward/citedby.url?scp=77953390683&partnerID=8YFLogxK
U2 - 10.1517/17530050903032646
DO - 10.1517/17530050903032646
M3 - Article
VL - 3
SP - 371
EP - 380
JO - Expert Opinion on Medical Diagnostics
JF - Expert Opinion on Medical Diagnostics
SN - 1753-0059
IS - 4
ER -