Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery

Joel C. Sunshine, Corey J. Bishop, Jordan Green

Research output: Contribution to journalArticle

Abstract

Nonviral systems for nucleic acid delivery offer a host of potential advantages compared with viruses, including reduced toxicity and immunogenicity, increased ease of production and less stringent vector size limitations, but remain far less efficient than their viral counterparts. In this article we review recent advances in the delivery of nucleic acids using polymeric and inorganic vectors. We discuss the wide range of materials being designed and evaluated for these purposes while considering the physical requirements and barriers to entry that these agents face and reviewing recent novel approaches towards improving delivery with respect to each of these barriers. Furthermore, we provide a brief overview of past and ongoing nonviral gene therapy clinical trials. We conclude with a discussion of multifunctional nucleic acid carriers and future directions.

Original languageEnglish (US)
Pages (from-to)493-521
Number of pages29
JournalTherapeutic Delivery
Volume2
Issue number4
DOIs
StatePublished - Apr 2011

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Nucleic Acids
Architectural Accessibility
Genetic Therapy
Clinical Trials
Viruses
Direction compound

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery. / Sunshine, Joel C.; Bishop, Corey J.; Green, Jordan.

In: Therapeutic Delivery, Vol. 2, No. 4, 04.2011, p. 493-521.

Research output: Contribution to journalArticle

Sunshine, Joel C. ; Bishop, Corey J. ; Green, Jordan. / Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery. In: Therapeutic Delivery. 2011 ; Vol. 2, No. 4. pp. 493-521.
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