Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

Robert H. Dworkin, Miroslav Backonja, Michael C. Rowbotham, Robert R. Allen, Charles R. Argoff, Gary J. Bennett, M. Catherine Bushnell, John T. Farrar, Bradley S. Galer, Jennifer Haythornthwaite, David J. Hewitt, John D. Loeser, Mitchell B. Max, Mario Saltarelli, Kenneth E. Schmader, Christoph Stein, David Thompson, Dennis C. Turk, Mark S. Wallace, Linda R. WatkinsSharon M. Weinstein

Research output: Contribution to journalArticle

Abstract

Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

Original languageEnglish (US)
Pages (from-to)1524-1534
Number of pages11
JournalArchives of Neurology
Volume60
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

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Neuralgia
Tramadol
Tricyclic Antidepressive Agents
Peripheral Nervous System
Therapeutics
Lidocaine
Research
Chronic Pain
Opioid Analgesics
Central Nervous System
Randomized Controlled Trials
Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dworkin, R. H., Backonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C. R., Bennett, G. J., ... Weinstein, S. M. (2003). Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations. Archives of Neurology, 60(11), 1524-1534. https://doi.org/10.1001/archneur.60.11.1524

Advances in Neuropathic Pain : Diagnosis, Mechanisms, and Treatment Recommendations. / Dworkin, Robert H.; Backonja, Miroslav; Rowbotham, Michael C.; Allen, Robert R.; Argoff, Charles R.; Bennett, Gary J.; Bushnell, M. Catherine; Farrar, John T.; Galer, Bradley S.; Haythornthwaite, Jennifer; Hewitt, David J.; Loeser, John D.; Max, Mitchell B.; Saltarelli, Mario; Schmader, Kenneth E.; Stein, Christoph; Thompson, David; Turk, Dennis C.; Wallace, Mark S.; Watkins, Linda R.; Weinstein, Sharon M.

In: Archives of Neurology, Vol. 60, No. 11, 11.2003, p. 1524-1534.

Research output: Contribution to journalArticle

Dworkin, RH, Backonja, M, Rowbotham, MC, Allen, RR, Argoff, CR, Bennett, GJ, Bushnell, MC, Farrar, JT, Galer, BS, Haythornthwaite, J, Hewitt, DJ, Loeser, JD, Max, MB, Saltarelli, M, Schmader, KE, Stein, C, Thompson, D, Turk, DC, Wallace, MS, Watkins, LR & Weinstein, SM 2003, 'Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations', Archives of Neurology, vol. 60, no. 11, pp. 1524-1534. https://doi.org/10.1001/archneur.60.11.1524
Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ et al. Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations. Archives of Neurology. 2003 Nov;60(11):1524-1534. https://doi.org/10.1001/archneur.60.11.1524
Dworkin, Robert H. ; Backonja, Miroslav ; Rowbotham, Michael C. ; Allen, Robert R. ; Argoff, Charles R. ; Bennett, Gary J. ; Bushnell, M. Catherine ; Farrar, John T. ; Galer, Bradley S. ; Haythornthwaite, Jennifer ; Hewitt, David J. ; Loeser, John D. ; Max, Mitchell B. ; Saltarelli, Mario ; Schmader, Kenneth E. ; Stein, Christoph ; Thompson, David ; Turk, Dennis C. ; Wallace, Mark S. ; Watkins, Linda R. ; Weinstein, Sharon M. / Advances in Neuropathic Pain : Diagnosis, Mechanisms, and Treatment Recommendations. In: Archives of Neurology. 2003 ; Vol. 60, No. 11. pp. 1524-1534.
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