Advances in microfluidic PCR for point-of-care infectious disease diagnostics

Seungkyung Park, Yi Zhang, Shin Lin, Tza Huei Wang, Samuel Yang

Research output: Contribution to journalReview articlepeer-review

Abstract

Global burdens from existing or emerging infectious diseases emphasize the need for point-of-care (POC) diagnostics to enhance timely recognition and intervention. Molecular approaches based on PCR methods have made significant inroads by improving detection time and accuracy but are still largely hampered by resource-intensive processing in centralized laboratories, thereby precluding their routine bedside- or field-use. Microfluidic technologies have enabled miniaturization of PCR processes onto a chip device with potential benefits including speed, cost, portability, throughput, and automation. In this review, we provide an overview of recent advances in microfluidic PCR technologies and discuss practical issues and perspectives related to implementing them into infectious disease diagnostics.

Original languageEnglish (US)
Pages (from-to)830-839
Number of pages10
JournalBiotechnology Advances
Volume29
Issue number6
DOIs
StatePublished - Nov 2011

Keywords

  • Diagnostic methods
  • Infectious disease
  • Microfluidic
  • PCR
  • Point-of-care

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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