Advances in mechanisms of asthma, allergy, and immunology in 2011

Joshua A. Boyce, Bruce Bochner, Fred D. Finkelman, Marc E. Rothenberg

Research output: Contribution to journalArticle

Abstract

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T H17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalThe Journal of Allergy and Clinical Immunology
Volume129
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Allergy and Immunology
Allergens
Asthma
Immunologic Desensitization
Cytokines
Therapeutics
anti-IgE antibodies

Keywords

  • calcitonin gene-related peptide
  • cyclic AMP
  • dendritic cell
  • facilitated antigen binding
  • facilitated antigen presentation
  • Galactose-α-1,3-galactose
  • genome-wide association study
  • interferon
  • lipopolysaccharide
  • Toll-like receptor
  • toluidine diisothiocyanate
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Advances in mechanisms of asthma, allergy, and immunology in 2011. / Boyce, Joshua A.; Bochner, Bruce; Finkelman, Fred D.; Rothenberg, Marc E.

In: The Journal of Allergy and Clinical Immunology, Vol. 129, No. 2, 02.2012, p. 335-341.

Research output: Contribution to journalArticle

Boyce, Joshua A. ; Bochner, Bruce ; Finkelman, Fred D. ; Rothenberg, Marc E. / Advances in mechanisms of asthma, allergy, and immunology in 2011. In: The Journal of Allergy and Clinical Immunology. 2012 ; Vol. 129, No. 2. pp. 335-341.
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