Advances in mechanisms of asthma, allergy, and immunology in 2011

Joshua A. Boyce; Bruce Bochner; Fred D. Finkelman; Marc E. Rothenberg

doi:10.1016/j.jaci.2011.12.968

Advances in mechanisms of asthma, allergy, and immunology in 2011

Joshua A. Boyce, Bruce Bochner, Fred D. Finkelman, Marc E. Rothenberg

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T _H 17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.

Original language	English (US)
Pages (from-to)	335-341
Number of pages	7
Journal	Journal of Allergy and Clinical Immunology
Volume	129
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2011.12.968
State	Published - Feb 2012
Externally published	Yes

Keywords

Galactose-α-1,3-galactose
Toll-like receptor
calcitonin gene-related peptide
cyclic AMP
dendritic cell
facilitated antigen binding
facilitated antigen presentation
genome-wide association study
interferon
lipopolysaccharide
toluidine diisothiocyanate
vascular endothelial growth factor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2011.12.968

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title = "Advances in mechanisms of asthma, allergy, and immunology in 2011",

abstract = " 2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T H 17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.",

keywords = "Galactose-α-1,3-galactose, Toll-like receptor, calcitonin gene-related peptide, cyclic AMP, dendritic cell, facilitated antigen binding, facilitated antigen presentation, genome-wide association study, interferon, lipopolysaccharide, toluidine diisothiocyanate, vascular endothelial growth factor",

author = "Boyce, {Joshua A.} and Bruce Bochner and Finkelman, {Fred D.} and Rothenberg, {Marc E.}",

note = "Funding Information: Disclosure of potential conflict of interest: B. Bochner has received consulting fees from Sanofi-Aventis and United States Diagnostics Standards; has received research support from the NIAID, NHLBI, and the Dana Foundation ; and is Editor in Chief for the Up-to-Date Allergy & Immunology section. M. E. Rothenberg has equity interest in Cephalon; is a consultant and Chief Scientific Office for Immune Pharmaceuticals; has received research support from the National Institutes of Health, FAAN, and the Department of Defense ; is on the APFED Medical Advisory Board; and is on the International Eosinophil Society Executive Council. The rest of the authors declare that they have no relevant conflicts of interest. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2012",

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doi = "10.1016/j.jaci.2011.12.968",

language = "English (US)",

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KW - facilitated antigen presentation

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KW - vascular endothelial growth factor

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Advances in mechanisms of asthma, allergy, and immunology in 2011

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