Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip

Wesley A. Anderson, Alexander Bosak, Helena T. Hogberg, Thomas Hartung, Michael J. Moore

Research output: Contribution to journalReview articlepeer-review

Abstract

Microphysiological systems (MPS) designed to study the complexities of the peripheral and central nervous systems have made marked improvements over the years and have allowed researchers to assess in two and three dimensions the functional interconnectivity of neuronal tissues. The recent generation of brain organoids has further propelled the field into the nascent recapitulation of structural, functional, and effective connectivities which are found within the native human nervous system. Herein, we will review advances in culture methodologies, focused especially on those of human tissues, which seek to bridge the gap from 2D cultures to hierarchical and defined 3D MPS with the end goal of developing a robust nervous system-on-a-chip platform. These advances have far-reaching implications within basic science, pharmaceutical development, and translational medicine disciplines.

Original languageEnglish (US)
Pages (from-to)191-206
Number of pages16
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume57
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • 3D culture
  • Brain organoids
  • Microengineering
  • Microphysiological systems
  • Nerve-on-a-chip
  • Neuroscience

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

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