TY - JOUR
T1 - Advanced nanotherapies to promote neuroregeneration in the injured newborn brain
AU - Arteaga Cabeza, Olatz
AU - Mikrogeorgiou, Alkisti
AU - Kannan, Sujatha
AU - Ferriero, Donna M.
N1 - Funding Information:
This work was funded by NS097299 (Dr. Ferriero). Olatz Arteaga Cabeza was partially supported by a research fellowship from Fundacion Alfonso Martın Escudero (FAME).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/8
Y1 - 2019/8
N2 - Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been adequately explored in this unique age group. In this perspective review, we describe current efforts that promote neuroprotection and potential targets that are unique to the developing brain, which can be leveraged to facilitate neuroregeneration.
AB - Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been adequately explored in this unique age group. In this perspective review, we describe current efforts that promote neuroprotection and potential targets that are unique to the developing brain, which can be leveraged to facilitate neuroregeneration.
KW - Dendrimers
KW - Gene therapy
KW - Growth factors
KW - Nanoparticles
KW - Neurotrophic factors
KW - PAMAM
KW - Stem cells
KW - Stroke
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U2 - 10.1016/j.addr.2019.10.005
DO - 10.1016/j.addr.2019.10.005
M3 - Review article
C2 - 31678359
AN - SCOPUS:85075507613
SN - 0169-409X
VL - 148
SP - 19
EP - 37
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -