Advanced nanotherapies to promote neuroregeneration in the injured newborn brain

Olatz Arteaga Cabeza, Alkisti Mikrogeorgiou, Sujatha Kannan, Donna M. Ferriero

Research output: Contribution to journalReview articlepeer-review

Abstract

Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been adequately explored in this unique age group. In this perspective review, we describe current efforts that promote neuroprotection and potential targets that are unique to the developing brain, which can be leveraged to facilitate neuroregeneration.

Original languageEnglish (US)
Pages (from-to)19-37
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume148
DOIs
StatePublished - Aug 2019

Keywords

  • Dendrimers
  • Gene therapy
  • Growth factors
  • Nanoparticles
  • Neurotrophic factors
  • PAMAM
  • Stem cells
  • Stroke

ASJC Scopus subject areas

  • Pharmaceutical Science

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