Advanced MRI strategies for assessing spinal cord injury

Research output: Contribution to journalArticle

Abstract

Advanced magnetic resonance (MR) approaches permit the noninvasive quantification of macromolecular, functional, and physiological properties of biological tissues. In this chapter, we review the application of advanced MR techniques to the spinal cord. Macromolecular properties of the spinal cord can be studied using magnetization transfer (MT) MR, diffusion tensor imaging (DTI), Q-space diffusion spectroscopy, and selective detection of myelin water. The functional and metabolic status of the spinal cord can be studied using functional MRI (fMRI), perfusion imaging, and magnetic resonance spectroscopy (MRS). Finally, we consider the outlook for advanced MR studies in persons in whom metal hardware has been implanted to stabilize the cord. In spite of the spinal cord's diminutive size, its location deep within the body, and constant motion, recent work shows that the spinal cord can be studied using these advanced MR approaches.

Original languageEnglish (US)
Pages (from-to)85-101
Number of pages17
JournalHandbook of Clinical Neurology
Volume109
DOIs
StatePublished - 2012

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Spinal Cord Injuries
Magnetic Resonance Spectroscopy
Spinal Cord
Diffusion Tensor Imaging
Perfusion Imaging
Myelin Sheath
Spectrum Analysis
Metals
Magnetic Resonance Imaging
Water

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Advanced MRI strategies for assessing spinal cord injury. / Smith, Seth A.; Pekar, James J; Van Zijl, Peter C.

In: Handbook of Clinical Neurology, Vol. 109, 2012, p. 85-101.

Research output: Contribution to journalArticle

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