Advanced contrast-enhanced mri for looking beyond the lumen to predict stroke: Building a risk profile for carotid plaque

Research output: Contribution to journalArticle

Abstract

Carotid plaque MRI can identify components indicative of stroke risk, including the thin/ruptured fibrous cap and lipid core. Gadolinium contrast, typically administered for routine MR angiography acquisitions, can be used to improve plaque characterization, extending risk assessment beyond the plaque's hemodynamic impact on the lumen. Gadolinium preferentially enhances the cap, improves reliability of vessel wall measurements, and highlights neovessels, improving stroke risk stratification. Additionally, the precontrast series from the contrast-enhanced MR angiography can help identify intraplaque hemorrhage, another important risk marker. Prospective validation of these features is needed to develop a carotid plaque risk profile for clinical implementation.

Original languageEnglish (US)
Pages (from-to)S12-S16
JournalStroke
Volume41
Issue number10 SUPPL. 1
DOIs
StatePublished - Oct 1 2010

Keywords

  • MRI
  • atherosclerosis
  • carotid artery
  • carotid plaque
  • carotid stenosis
  • imaging
  • magnetic resonance
  • risk factors
  • stroke risk

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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