TY - JOUR
T1 - Advanced cognitive training for breast cancer survivors
T2 - A randomized controlled trial
AU - Von Ah, Diane
AU - Carpenter, Janet S.
AU - Saykin, Andrew
AU - Monahan, Patrick
AU - Wu, Jingwei
AU - Yu, Menggang
AU - Rebok, George
AU - Ball, Karlene
AU - Schneider, Bryan
AU - Weaver, Michael
AU - Tallman, Eileen
AU - Unverzagt, Fred
N1 - Funding Information:
Acknowledgments This study was supported by Robert Wood Johnson Foundation Nurse Faculty Scholar Program (#64194), American Cancer Society Institutional Research Grant (#84-002-25), Indiana University School of Nursing Center for Enhancing Quality of Life in Chronic Illness and the Mary Margaret Walther Program of the Walther Cancer Institute (#0097.01). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Robert Wood Johnson Foundation, which funded this trial. The funding agency had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript. Dr. Patrick Monahan had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
PY - 2012/10
Y1 - 2012/10
N2 - The purpose of this study was to evaluate the preliminary efficacy and satisfaction/acceptability of training in memory or speed of processing versus wait-list control for improving cognitive function in breast cancer survivors. 82 breast cancer survivors completed a threegroup randomized, controlled trial. Primary outcomes were objective neuropsychological tests of memory and speed of processing. Secondary outcomes were perceived cognitive functioning, symptom distress (mood disturbance, anxiety, and fatigue), quality of life, and intervention satisfaction/ acceptability. Data were collected at baseline, post-intervention, and 2-month follow-up. Using repeated-measures mixed-linear ANCOVA models, each intervention was compared to wait-list control while adjusting for age, education, and baseline measures. The effect sizes for differences in means and the reliable improvement percentage were reported. The results show that domainspecific effects were seen for both interventions: memory training improved memory performance at 2-month follow-up (p = 0.036, d = 0.59); speed of processing training improved processing speed post-intervention (p = 0.040, d = 0.55) and 2-month follow-up (p = 0.016; d = 0.67). Transfer effects to non-trained domains were seen for speed of processing training with improved memory postintervention (p = 0.007, d = 0.75) and 2-month follow-up (p = 0.004, d = 0.82). Both interventions were associated with improvements in perceived cognitive functioning, symptom distress, and quality of life. Ratings of satisfaction/ acceptability were high for both interventions. It was concluded that while both interventions appeared promising, speed of processing training resulted in immediate and durable improvements in objective measures of processing speed and verbal memory. Speed of processing training may have broader benefits in this clinical population.
AB - The purpose of this study was to evaluate the preliminary efficacy and satisfaction/acceptability of training in memory or speed of processing versus wait-list control for improving cognitive function in breast cancer survivors. 82 breast cancer survivors completed a threegroup randomized, controlled trial. Primary outcomes were objective neuropsychological tests of memory and speed of processing. Secondary outcomes were perceived cognitive functioning, symptom distress (mood disturbance, anxiety, and fatigue), quality of life, and intervention satisfaction/ acceptability. Data were collected at baseline, post-intervention, and 2-month follow-up. Using repeated-measures mixed-linear ANCOVA models, each intervention was compared to wait-list control while adjusting for age, education, and baseline measures. The effect sizes for differences in means and the reliable improvement percentage were reported. The results show that domainspecific effects were seen for both interventions: memory training improved memory performance at 2-month follow-up (p = 0.036, d = 0.59); speed of processing training improved processing speed post-intervention (p = 0.040, d = 0.55) and 2-month follow-up (p = 0.016; d = 0.67). Transfer effects to non-trained domains were seen for speed of processing training with improved memory postintervention (p = 0.007, d = 0.75) and 2-month follow-up (p = 0.004, d = 0.82). Both interventions were associated with improvements in perceived cognitive functioning, symptom distress, and quality of life. Ratings of satisfaction/ acceptability were high for both interventions. It was concluded that while both interventions appeared promising, speed of processing training resulted in immediate and durable improvements in objective measures of processing speed and verbal memory. Speed of processing training may have broader benefits in this clinical population.
KW - Breast cancer survivors
KW - Memory
KW - Quality of life
KW - Speed of processing
KW - Symptom distress
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U2 - 10.1007/s10549-012-2210-6
DO - 10.1007/s10549-012-2210-6
M3 - Article
C2 - 22918524
AN - SCOPUS:84866551599
SN - 0167-6806
VL - 135
SP - 799
EP - 809
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -