Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP

Young H. Ko; Barbara L. Smith; Yuchuan Wang; Martin G. Pomper; David A. Rini; Michael S. Torbenson; Joanne Hullihen; Peter L. Pedersen

doi:10.1016/j.bbrc.2004.09.047

Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP

Young H. Ko, Barbara L. Smith, Yuchuan Wang, Martin G. Pomper, David A. Rini, Michael S. Torbenson, Joanne Hullihen, Peter L. Pedersen

School of Medicine

Research output: Contribution to journal › Article › peer-review

291 Scopus citations

Abstract

A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3 cm) developed and were treated with the alkylating agent 3-bromopyruvate, a lactate/pyruvate analog shown here to selectively deplete ATP and induce cell death. In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers.

Original language	English (US)
Pages (from-to)	269-275
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2004.09.047
State	Published - Nov 5 2004

Keywords

3-Bromopyruvic acid
ATP depletion
Advanced cancers
Cancer therapy
Liver/colon cancer

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.09.047

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title = "Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP",

abstract = "A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3 cm) developed and were treated with the alkylating agent 3-bromopyruvate, a lactate/pyruvate analog shown here to selectively deplete ATP and induce cell death. In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers.",

keywords = "3-Bromopyruvic acid, ATP depletion, Advanced cancers, Cancer therapy, Liver/colon cancer",

author = "Ko, {Young H.} and Smith, {Barbara L.} and Yuchuan Wang and Pomper, {Martin G.} and Rini, {David A.} and Torbenson, {Michael S.} and Joanne Hullihen and Pedersen, {Peter L.}",

note = "Funding Information: This work was supported by start-up funds to Y.H.K. from the Department of Radiology, by NIH Grants CA 10951 and CA 80118 to P.L.P. and Grant CA92871 to M.G.P. ",

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AU - Ko, Young H.

AU - Smith, Barbara L.

AU - Wang, Yuchuan

AU - Pomper, Martin G.

AU - Rini, David A.

AU - Torbenson, Michael S.

AU - Hullihen, Joanne

AU - Pedersen, Peter L.

N1 - Funding Information: This work was supported by start-up funds to Y.H.K. from the Department of Radiology, by NIH Grants CA 10951 and CA 80118 to P.L.P. and Grant CA92871 to M.G.P.

PY - 2004/11/5

Y1 - 2004/11/5

N2 - A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3 cm) developed and were treated with the alkylating agent 3-bromopyruvate, a lactate/pyruvate analog shown here to selectively deplete ATP and induce cell death. In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers.

AB - A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3 cm) developed and were treated with the alkylating agent 3-bromopyruvate, a lactate/pyruvate analog shown here to selectively deplete ATP and induce cell death. In all 19 treated animals advanced cancers were eradicated without apparent toxicity or recurrence. These findings attest to the feasibility of completely destroying advanced, highly glycolytic cancers.

KW - 3-Bromopyruvic acid

KW - ATP depletion

KW - Advanced cancers

KW - Cancer therapy

KW - Liver/colon cancer

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Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP

Abstract

Keywords

ASJC Scopus subject areas

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