Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry

John A. Shepherd, Markus J. Sommer, Bo Fan, Cassidy Powers, Lynda Stranix-Chibanda, Amanda Zadzilka, Michael Basar, Kathy George, Cynthia Mukwasi-Kahari, George Siberry

Research output: Contribution to journalArticle

Abstract

Objective To evaluate a novel technique designed to reduce the negative impact of motion artifacts in infant dual-energy X-ray absorptiometry (DXA) scans. Study design Using cross-sectional data from a large multicenter study, we developed and tested advanced methods for infant scan analysis. Newborns (n = 750) received spine and whole-body DXA scans with up to 3 attempts to acquire a motion free scan. Precision of infant DXA was estimated from visits with multiple valid scans. Accuracy of regional reflection, fusion, and omission techniques was estimated by comparing modified scans to unmodified valid scans. The effectiveness of the acquisition and analysis protocol was represented by the reduction in rate of failure to acquire valid results from infant visits. Results For infant whole-body DXA, arm reflection and all fusion techniques caused no significant changes to bone mineral content, bone mineral density, bone area, total mass, fat mass, lean mass, and percentage fat. Leg reflection and arm/leg dual-reflection caused significant changes to total mass, but the percentage change remained small. For infant spine DXA, fusion and omission caused no significant changes. Advanced analysis techniques reduced the failure rate of whole-body scanning from 20.8% to 9.3% and the failure rate of spine scanning from 8.9% to 2.4%. Conclusions Advanced analysis techniques significantly reduced the impact of motion artifacts on infant DXA scans. We suggest this protocol be used in future infant DXA research and clinical practice.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalJournal of Pediatrics
Volume181
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Fingerprint

Body Weights and Measures
Photon Absorptiometry
Body Composition
Bone and Bones
Spine
Bone Density
Artifacts
Leg
Arm
Fats
Whole Body Imaging
Multicenter Studies
Newborn Infant

Keywords

  • body composition
  • bone mineral density
  • precision

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Shepherd, J. A., Sommer, M. J., Fan, B., Powers, C., Stranix-Chibanda, L., Zadzilka, A., ... Siberry, G. (2017). Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry. Journal of Pediatrics, 181, 248-253. https://doi.org/10.1016/j.jpeds.2016.10.040

Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry. / Shepherd, John A.; Sommer, Markus J.; Fan, Bo; Powers, Cassidy; Stranix-Chibanda, Lynda; Zadzilka, Amanda; Basar, Michael; George, Kathy; Mukwasi-Kahari, Cynthia; Siberry, George.

In: Journal of Pediatrics, Vol. 181, 01.02.2017, p. 248-253.

Research output: Contribution to journalArticle

Shepherd, JA, Sommer, MJ, Fan, B, Powers, C, Stranix-Chibanda, L, Zadzilka, A, Basar, M, George, K, Mukwasi-Kahari, C & Siberry, G 2017, 'Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry', Journal of Pediatrics, vol. 181, pp. 248-253. https://doi.org/10.1016/j.jpeds.2016.10.040
Shepherd, John A. ; Sommer, Markus J. ; Fan, Bo ; Powers, Cassidy ; Stranix-Chibanda, Lynda ; Zadzilka, Amanda ; Basar, Michael ; George, Kathy ; Mukwasi-Kahari, Cynthia ; Siberry, George. / Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry. In: Journal of Pediatrics. 2017 ; Vol. 181. pp. 248-253.
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