Adult vector control, mosquito ecology and malaria transmission

Oliver J. Brady, H. Charles J Godfray, Andrew J. Tatem, Peter W. Gething, Justin M. Cohen, F. Ellis McKenzie, T. Alex Perkins, Robert C. Reiner, Lucy S. Tusting, Thomas W. Scott, Steven W. Lindsay, Simon I. Hay, David L. Smith

Research output: Contribution to journalArticle

Abstract

Background: Standard advice regarding vector control is to prefer interventions that reduce the lifespan of adult mosquitoes. The basis for this advice is a decades-old sensitivity analysis of 'vectorial capacity', a concept relevant for most malaria transmission models and based solely on adult mosquito population dynamics. Recent advances in micro-simulation models offer an opportunity to expand the theory of vectorial capacity to include both adult and juvenile mosquito stages in the model. Methods: In this study we revisit arguments about transmission and its sensitivity to mosquito bionomic parameters using an elasticity analysis of developed formulations of vectorial capacity. Results: We show that reducing adult survival has effects on both adult and juvenile population size, which are significant for transmission and not accounted for in traditional formulations of vectorial capacity. The elasticity of these effects is dependent on various mosquito population parameters, which we explore. Overall, control is most sensitive to methods that affect adult mosquito mortality rates, followed by blood feeding frequency, human blood feeding habit, and lastly, to adult mosquito population density. Conclusions: These results emphasise more strongly than ever the sensitivity of transmission to adult mosquito mortality, but also suggest the high potential of combinations of interventions including larval source management. This must be done with caution, however, as policy requires a more careful consideration of costs, operational difficulties and policy goals in relation to baseline transmission.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalInternational Health
Volume7
Issue number2
DOIs
StatePublished - Jan 23 2015
Externally publishedYes

Fingerprint

Mosquito Control
Ecology
Culicidae
Malaria
ecology
Elasticity
Population Density
mortality
Mortality
Mosquito Vectors
Population Dynamics
life-span
population density
population development
simulation model
Habits
habits
Costs and Cost Analysis
Survival

Keywords

  • Larval control
  • Malaria control policy
  • Micro-simulation models
  • Plasmodium falciparum
  • Plasmodium vivax

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Medicine(all)

Cite this

Brady, O. J., Godfray, H. C. J., Tatem, A. J., Gething, P. W., Cohen, J. M., Ellis McKenzie, F., ... Smith, D. L. (2015). Adult vector control, mosquito ecology and malaria transmission. International Health, 7(2), 121-129. https://doi.org/10.1093/inthealth/ihv010

Adult vector control, mosquito ecology and malaria transmission. / Brady, Oliver J.; Godfray, H. Charles J; Tatem, Andrew J.; Gething, Peter W.; Cohen, Justin M.; Ellis McKenzie, F.; Alex Perkins, T.; Reiner, Robert C.; Tusting, Lucy S.; Scott, Thomas W.; Lindsay, Steven W.; Hay, Simon I.; Smith, David L.

In: International Health, Vol. 7, No. 2, 23.01.2015, p. 121-129.

Research output: Contribution to journalArticle

Brady, OJ, Godfray, HCJ, Tatem, AJ, Gething, PW, Cohen, JM, Ellis McKenzie, F, Alex Perkins, T, Reiner, RC, Tusting, LS, Scott, TW, Lindsay, SW, Hay, SI & Smith, DL 2015, 'Adult vector control, mosquito ecology and malaria transmission', International Health, vol. 7, no. 2, pp. 121-129. https://doi.org/10.1093/inthealth/ihv010
Brady OJ, Godfray HCJ, Tatem AJ, Gething PW, Cohen JM, Ellis McKenzie F et al. Adult vector control, mosquito ecology and malaria transmission. International Health. 2015 Jan 23;7(2):121-129. https://doi.org/10.1093/inthealth/ihv010
Brady, Oliver J. ; Godfray, H. Charles J ; Tatem, Andrew J. ; Gething, Peter W. ; Cohen, Justin M. ; Ellis McKenzie, F. ; Alex Perkins, T. ; Reiner, Robert C. ; Tusting, Lucy S. ; Scott, Thomas W. ; Lindsay, Steven W. ; Hay, Simon I. ; Smith, David L. / Adult vector control, mosquito ecology and malaria transmission. In: International Health. 2015 ; Vol. 7, No. 2. pp. 121-129.
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