Adult neurogenesis and cell cycle regulation in the crustacean olfactory pathway: From glial precursors to differentiated neurons

Jeremy M. Sullivan, David C. Sandeman, Jeanne L. Benton, Barbara S. Beltz

Research output: Contribution to journalReview article

Abstract

Adult neurogenesis is a characteristic feature of the olfactory pathways of decapod crustaceans. In crayfish and clawed lobsters, adult-born neurons are the progeny of precursor cells with glial characteristics located in a neurogenic niche on the ventral surface of the brain. The daughters of these precursor cells migrate during S and G2 stages of the cell cycle along glial fibers to lateral (cluster 10) and medial (cluster 9) proliferation zones. Here, they divide (M phase) producing offspring that differentiate into olfactory interneurons. The complete lineage of cells producing neurons in these animals, therefore, is arranged along the migratory stream according to cell cycle stage. We have exploited this model to examine the influence of environmental and endogenous factors on adult neurogenesis. We find that increased levels of serotonin upregulate neuronal production, as does maintaining animals in an enriched (versus deprived) environment or augmenting their diet with omega-3 fatty acids; increased levels of nitric oxide, on the other hand, decrease the rate of neurogenesis. The features of the neurogenic niche and migratory streams, and the fact that these continue to function in vitro, provide opportunities unavailable in other organisms to explore the sequence of cellular and molecular events leading to the production of new neurons in adult brains.

Original languageEnglish (US)
Pages (from-to)527-542
Number of pages16
JournalJournal of Molecular Histology
Volume38
Issue number6
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Migratory stream
  • Neurogenic niche
  • Neuronal proliferation

ASJC Scopus subject areas

  • Histology
  • Physiology
  • Cell Biology

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