Adult 'fetal-like' erythropoiesis characterizes recovery from bone marrow transplantation

R. S. Weinberg, J. M. Schofield, A. L. Lenes, J. Brochstein, B. P. Alter

Research output: Contribution to journalArticle

Abstract

The transient fetal-like erythropoiesis which appears during recovery from bone marrow transplantation has now been examined at the level of erythroid progenitor cells. A 7-year-old boy with β+-thalassaemia major was studied during engraftment from his β-thalassaemia trait sister. Hb F and i antigen rose as expected. Macrocytosis never developed, but red cell size distribution became very heterogeneous. Bone marrow CFU-E and BFU-E were detected by 30 d, prior to the appearance of reticulocytes. Marrow erythroid progenitor cell numbers were normal by 146 d, while those in the blood became normal by 360 d. After transplantation globin synthesis ratios in erythroid colonies were diagnostic of thalassaemia trait, indicating engraftment. Individual erythroid colonies derived from both blood and marrow at all times during reconstitution showed no correlation of (G)γ and γ. Thus the fetal-like stress erythropoiesis of marrow expansion following transplantation was derived from adult and not fetal progenitor cells.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalBritish Journal of Haematology
Volume63
Issue number3
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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    Weinberg, R. S., Schofield, J. M., Lenes, A. L., Brochstein, J., & Alter, B. P. (1986). Adult 'fetal-like' erythropoiesis characterizes recovery from bone marrow transplantation. British Journal of Haematology, 63(3), 415-424.