Adult cerebellar glioblastoma: Understanding survival and prognostic factors using a population-based database from 1973 to 2009

Hadie Adams, Kaisorn L. Chaichana, Javier Avendaño, Brian Liu, Shaan M. Raza, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalArticle

Abstract

Objective: Glioblastoma (GB) is rarely found in the cerebellum. Because of its rarity, it is poorly understood if cerebellar GB (CGB) behaves similarly to supratentorial GB. Studies have been limited to case reports and small case series. A better understanding of CGB may help guide treatment strategies. Methods: Surveillance, Epidemiology and End Results database was analyzed from 1973 to 2009 for all adult patients with GB located in the cerebellum. Stepwise multivariate proportional hazards regression analyses were used to identify factors independently associated with survival. Results: Two hundred eight (0.9%) patients with CGB were identified from 23,329 GB patients with known locality. The mean age was 58 years. Median survival was 8 months, with 1-, 2- and 5-year survival rates of 21%, 13%, and 2%. When compared to supratentorial GB, CGB occurred in younger patients (58 ± 16 vs. 61 ± 13 years, P = 0.001), less commonly in Whites (85.6% vs. 91.3%, P = 0.005), and were smaller (3.7 ± 1.1 vs. 4.5 ± 1.7 cm, P = 0.001). A cerebellar location independently predicted poorer survival when compared to other GB locations (P = 0.048). In multivariate analysis for patients with CGB, younger age (P <0.001), Asian or Pacific Islander race (P = 0.046), and radiation therapy (P <0.001) were independently associated with prolonged survival. Conclusion: CGBs are difficult to analyze using institutional series because of their rarity. This study shows they are clinically different from supratentorial GB. Among patients with CGB, radiation therapy may prolong survival. This may help guide treatment strategies aimed at prolonging survival for patients with these extremely rare lesions.

Original languageEnglish (US)
JournalWorld Neurosurgery
Volume80
Issue number6
DOIs
StatePublished - Dec 2013

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Glioblastoma
Databases
Survival
Population
Cerebellum
Radiotherapy
Epidemiology
Multivariate Analysis
Survival Rate
Regression Analysis
Therapeutics

Keywords

  • Cerebellar
  • Cerebellum
  • Glioblastoma
  • Glioma
  • SEER
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Adult cerebellar glioblastoma : Understanding survival and prognostic factors using a population-based database from 1973 to 2009. / Adams, Hadie; Chaichana, Kaisorn L.; Avendaño, Javier; Liu, Brian; Raza, Shaan M.; Quiñones-Hinojosa, Alfredo.

In: World Neurosurgery, Vol. 80, No. 6, 12.2013.

Research output: Contribution to journalArticle

Adams, Hadie ; Chaichana, Kaisorn L. ; Avendaño, Javier ; Liu, Brian ; Raza, Shaan M. ; Quiñones-Hinojosa, Alfredo. / Adult cerebellar glioblastoma : Understanding survival and prognostic factors using a population-based database from 1973 to 2009. In: World Neurosurgery. 2013 ; Vol. 80, No. 6.
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abstract = "Objective: Glioblastoma (GB) is rarely found in the cerebellum. Because of its rarity, it is poorly understood if cerebellar GB (CGB) behaves similarly to supratentorial GB. Studies have been limited to case reports and small case series. A better understanding of CGB may help guide treatment strategies. Methods: Surveillance, Epidemiology and End Results database was analyzed from 1973 to 2009 for all adult patients with GB located in the cerebellum. Stepwise multivariate proportional hazards regression analyses were used to identify factors independently associated with survival. Results: Two hundred eight (0.9{\%}) patients with CGB were identified from 23,329 GB patients with known locality. The mean age was 58 years. Median survival was 8 months, with 1-, 2- and 5-year survival rates of 21{\%}, 13{\%}, and 2{\%}. When compared to supratentorial GB, CGB occurred in younger patients (58 ± 16 vs. 61 ± 13 years, P = 0.001), less commonly in Whites (85.6{\%} vs. 91.3{\%}, P = 0.005), and were smaller (3.7 ± 1.1 vs. 4.5 ± 1.7 cm, P = 0.001). A cerebellar location independently predicted poorer survival when compared to other GB locations (P = 0.048). In multivariate analysis for patients with CGB, younger age (P <0.001), Asian or Pacific Islander race (P = 0.046), and radiation therapy (P <0.001) were independently associated with prolonged survival. Conclusion: CGBs are difficult to analyze using institutional series because of their rarity. This study shows they are clinically different from supratentorial GB. Among patients with CGB, radiation therapy may prolong survival. This may help guide treatment strategies aimed at prolonging survival for patients with these extremely rare lesions.",
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AU - Adams, Hadie

AU - Chaichana, Kaisorn L.

AU - Avendaño, Javier

AU - Liu, Brian

AU - Raza, Shaan M.

AU - Quiñones-Hinojosa, Alfredo

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N2 - Objective: Glioblastoma (GB) is rarely found in the cerebellum. Because of its rarity, it is poorly understood if cerebellar GB (CGB) behaves similarly to supratentorial GB. Studies have been limited to case reports and small case series. A better understanding of CGB may help guide treatment strategies. Methods: Surveillance, Epidemiology and End Results database was analyzed from 1973 to 2009 for all adult patients with GB located in the cerebellum. Stepwise multivariate proportional hazards regression analyses were used to identify factors independently associated with survival. Results: Two hundred eight (0.9%) patients with CGB were identified from 23,329 GB patients with known locality. The mean age was 58 years. Median survival was 8 months, with 1-, 2- and 5-year survival rates of 21%, 13%, and 2%. When compared to supratentorial GB, CGB occurred in younger patients (58 ± 16 vs. 61 ± 13 years, P = 0.001), less commonly in Whites (85.6% vs. 91.3%, P = 0.005), and were smaller (3.7 ± 1.1 vs. 4.5 ± 1.7 cm, P = 0.001). A cerebellar location independently predicted poorer survival when compared to other GB locations (P = 0.048). In multivariate analysis for patients with CGB, younger age (P <0.001), Asian or Pacific Islander race (P = 0.046), and radiation therapy (P <0.001) were independently associated with prolonged survival. Conclusion: CGBs are difficult to analyze using institutional series because of their rarity. This study shows they are clinically different from supratentorial GB. Among patients with CGB, radiation therapy may prolong survival. This may help guide treatment strategies aimed at prolonging survival for patients with these extremely rare lesions.

AB - Objective: Glioblastoma (GB) is rarely found in the cerebellum. Because of its rarity, it is poorly understood if cerebellar GB (CGB) behaves similarly to supratentorial GB. Studies have been limited to case reports and small case series. A better understanding of CGB may help guide treatment strategies. Methods: Surveillance, Epidemiology and End Results database was analyzed from 1973 to 2009 for all adult patients with GB located in the cerebellum. Stepwise multivariate proportional hazards regression analyses were used to identify factors independently associated with survival. Results: Two hundred eight (0.9%) patients with CGB were identified from 23,329 GB patients with known locality. The mean age was 58 years. Median survival was 8 months, with 1-, 2- and 5-year survival rates of 21%, 13%, and 2%. When compared to supratentorial GB, CGB occurred in younger patients (58 ± 16 vs. 61 ± 13 years, P = 0.001), less commonly in Whites (85.6% vs. 91.3%, P = 0.005), and were smaller (3.7 ± 1.1 vs. 4.5 ± 1.7 cm, P = 0.001). A cerebellar location independently predicted poorer survival when compared to other GB locations (P = 0.048). In multivariate analysis for patients with CGB, younger age (P <0.001), Asian or Pacific Islander race (P = 0.046), and radiation therapy (P <0.001) were independently associated with prolonged survival. Conclusion: CGBs are difficult to analyze using institutional series because of their rarity. This study shows they are clinically different from supratentorial GB. Among patients with CGB, radiation therapy may prolong survival. This may help guide treatment strategies aimed at prolonging survival for patients with these extremely rare lesions.

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KW - Glioma

KW - SEER

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