Abstract
Knowledge about adrenoleukodystrophy (ALD), a disorder which was described first in 1923, has increased greatly during recent years. The principal biochemical abnormality, the presumed enzyme defect, and the gene defect, have been defined. A dietary therapy has been proposed and attracted world‐wide attention through a motion picture. Nevertheless, many questions remain and cannot be answered without a more fundamental understanding of pathology and pathogenesis. This article will provide a review of the history, clinical features, pathology, biochemistry, and the gene defect, and then appraise current efforts to clarify pathogenesis and develop therapeutic approaches.
Original language | English (US) |
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Pages (from-to) | 259-266 |
Number of pages | 8 |
Journal | Brain Pathology |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
- General Neuroscience
- Pathology and Forensic Medicine