Adrenoleukodystrophy: Molecular genetics, pathology, and Lorenzo's oil

H. W. Moser, J. M. Powers, Kirby D. Smith

Research output: Contribution to journalArticle

Abstract

Knowledge about adrenoleukodystrophy (ALD), a disorder which was described first in 1923, has increased greatly during recent years. The principal biochemical abnormality, the presumed enzyme defect, and the gene defect, have been defined. A dietary therapy has been proposed and attracted world-wide attention through a motion picture. Nevertheless, many questions remain and cannot be answered without a more fundamental understanding of pathology and pathogenesis. This article will provide a review of the history, clinical features, pathology, biochemistry, and the gene defect, and then appraise current efforts to clarify pathogenesis and develop therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalBrain Pathology
Volume5
Issue number3
StatePublished - 1995

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Adrenoleukodystrophy
Molecular Pathology
Molecular Biology
Clinical Pathology
Motion Pictures
Biochemistry
Genes
History
Pathology
Enzymes
Therapeutics
Lorenzo's oil

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Adrenoleukodystrophy : Molecular genetics, pathology, and Lorenzo's oil. / Moser, H. W.; Powers, J. M.; Smith, Kirby D.

In: Brain Pathology, Vol. 5, No. 3, 1995, p. 259-266.

Research output: Contribution to journalArticle

Moser, H. W. ; Powers, J. M. ; Smith, Kirby D. / Adrenoleukodystrophy : Molecular genetics, pathology, and Lorenzo's oil. In: Brain Pathology. 1995 ; Vol. 5, No. 3. pp. 259-266.
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