Adrenocortical Carcinoma

Impact of Surgical Margin Status on Long-Term Outcomes

Georgios Antonios Margonis, Yuhree Kim, Jason D Prescott, Thuy B. Tran, Lauren M. Postlewait, Shishir K. Maithel, Tracy S. Wang, Douglas B. Evans, Ioannis Hatzaras, Rivfka Shenoy, John E. Phay, Kara Keplinger, Ryan C. Fields, Linda X. Jin, Sharon M. Weber, Ahmed Salem, Jason K. Sicklick, Shady Gad, Adam C. Yopp, John C. Mansour & 8 others Quan Yang Duh, Natalie Seiser, Carmen C. Solorzano, Colleen M. Kiernan, Konstantinos I. Votanopoulos, Edward A. Levine, George A. Poultsides, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

Background: The influence of surgical margin status on long-term outcomes of patients undergoing adrenal resection for ACC remains not well defined. We studied the impact of surgical tumor margin status on recurrence-free survival (RFS) and overall survival (OS) of patients undergoing resection for ACC. Methods: A total of 165 patients who underwent adrenal resection for ACC and met inclusion criteria were identified form a multi-institutional database. Clinicopathological data, pathologic margin status, and long-term outcomes were assessed. Patients were stratified into two groups based on margin status: R0 (margin >1 mm) versus R1. Results: R0 resection was achieved in 126 patients (76.4 %), whereas 39 patients (23.6 %) had an R1 resection. Median and 5-year OS for patients undergoing R0 resection were 96.3 months and 64.8 % versus 25.1 months and 33.8 % for patients undergoing an R1 resection (both p 

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalAnnals of Surgical Oncology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Adrenocortical Carcinoma
Survival
Margins of Excision
Databases
Recurrence

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Margonis, G. A., Kim, Y., Prescott, J. D., Tran, T. B., Postlewait, L. M., Maithel, S. K., ... Pawlik, T. M. (2016). Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes. Annals of Surgical Oncology, 23(1), 134-141. https://doi.org/10.1245/s10434-015-4803-x

Adrenocortical Carcinoma : Impact of Surgical Margin Status on Long-Term Outcomes. / Margonis, Georgios Antonios; Kim, Yuhree; Prescott, Jason D; Tran, Thuy B.; Postlewait, Lauren M.; Maithel, Shishir K.; Wang, Tracy S.; Evans, Douglas B.; Hatzaras, Ioannis; Shenoy, Rivfka; Phay, John E.; Keplinger, Kara; Fields, Ryan C.; Jin, Linda X.; Weber, Sharon M.; Salem, Ahmed; Sicklick, Jason K.; Gad, Shady; Yopp, Adam C.; Mansour, John C.; Duh, Quan Yang; Seiser, Natalie; Solorzano, Carmen C.; Kiernan, Colleen M.; Votanopoulos, Konstantinos I.; Levine, Edward A.; Poultsides, George A.; Pawlik, Timothy M.

In: Annals of Surgical Oncology, Vol. 23, No. 1, 01.01.2016, p. 134-141.

Research output: Contribution to journalArticle

Margonis, GA, Kim, Y, Prescott, JD, Tran, TB, Postlewait, LM, Maithel, SK, Wang, TS, Evans, DB, Hatzaras, I, Shenoy, R, Phay, JE, Keplinger, K, Fields, RC, Jin, LX, Weber, SM, Salem, A, Sicklick, JK, Gad, S, Yopp, AC, Mansour, JC, Duh, QY, Seiser, N, Solorzano, CC, Kiernan, CM, Votanopoulos, KI, Levine, EA, Poultsides, GA & Pawlik, TM 2016, 'Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes', Annals of Surgical Oncology, vol. 23, no. 1, pp. 134-141. https://doi.org/10.1245/s10434-015-4803-x
Margonis, Georgios Antonios ; Kim, Yuhree ; Prescott, Jason D ; Tran, Thuy B. ; Postlewait, Lauren M. ; Maithel, Shishir K. ; Wang, Tracy S. ; Evans, Douglas B. ; Hatzaras, Ioannis ; Shenoy, Rivfka ; Phay, John E. ; Keplinger, Kara ; Fields, Ryan C. ; Jin, Linda X. ; Weber, Sharon M. ; Salem, Ahmed ; Sicklick, Jason K. ; Gad, Shady ; Yopp, Adam C. ; Mansour, John C. ; Duh, Quan Yang ; Seiser, Natalie ; Solorzano, Carmen C. ; Kiernan, Colleen M. ; Votanopoulos, Konstantinos I. ; Levine, Edward A. ; Poultsides, George A. ; Pawlik, Timothy M. / Adrenocortical Carcinoma : Impact of Surgical Margin Status on Long-Term Outcomes. In: Annals of Surgical Oncology. 2016 ; Vol. 23, No. 1. pp. 134-141.
@article{b5c282ac8ec44a29825b23dcc3885267,
title = "Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes",
abstract = "Background: The influence of surgical margin status on long-term outcomes of patients undergoing adrenal resection for ACC remains not well defined. We studied the impact of surgical tumor margin status on recurrence-free survival (RFS) and overall survival (OS) of patients undergoing resection for ACC. Methods: A total of 165 patients who underwent adrenal resection for ACC and met inclusion criteria were identified form a multi-institutional database. Clinicopathological data, pathologic margin status, and long-term outcomes were assessed. Patients were stratified into two groups based on margin status: R0 (margin >1 mm) versus R1. Results: R0 resection was achieved in 126 patients (76.4 {\%}), whereas 39 patients (23.6 {\%}) had an R1 resection. Median and 5-year OS for patients undergoing R0 resection were 96.3 months and 64.8 {\%} versus 25.1 months and 33.8 {\%} for patients undergoing an R1 resection (both p ",
author = "Margonis, {Georgios Antonios} and Yuhree Kim and Prescott, {Jason D} and Tran, {Thuy B.} and Postlewait, {Lauren M.} and Maithel, {Shishir K.} and Wang, {Tracy S.} and Evans, {Douglas B.} and Ioannis Hatzaras and Rivfka Shenoy and Phay, {John E.} and Kara Keplinger and Fields, {Ryan C.} and Jin, {Linda X.} and Weber, {Sharon M.} and Ahmed Salem and Sicklick, {Jason K.} and Shady Gad and Yopp, {Adam C.} and Mansour, {John C.} and Duh, {Quan Yang} and Natalie Seiser and Solorzano, {Carmen C.} and Kiernan, {Colleen M.} and Votanopoulos, {Konstantinos I.} and Levine, {Edward A.} and Poultsides, {George A.} and Pawlik, {Timothy M.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1245/s10434-015-4803-x",
language = "English (US)",
volume = "23",
pages = "134--141",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Adrenocortical Carcinoma

T2 - Impact of Surgical Margin Status on Long-Term Outcomes

AU - Margonis, Georgios Antonios

AU - Kim, Yuhree

AU - Prescott, Jason D

AU - Tran, Thuy B.

AU - Postlewait, Lauren M.

AU - Maithel, Shishir K.

AU - Wang, Tracy S.

AU - Evans, Douglas B.

AU - Hatzaras, Ioannis

AU - Shenoy, Rivfka

AU - Phay, John E.

AU - Keplinger, Kara

AU - Fields, Ryan C.

AU - Jin, Linda X.

AU - Weber, Sharon M.

AU - Salem, Ahmed

AU - Sicklick, Jason K.

AU - Gad, Shady

AU - Yopp, Adam C.

AU - Mansour, John C.

AU - Duh, Quan Yang

AU - Seiser, Natalie

AU - Solorzano, Carmen C.

AU - Kiernan, Colleen M.

AU - Votanopoulos, Konstantinos I.

AU - Levine, Edward A.

AU - Poultsides, George A.

AU - Pawlik, Timothy M.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: The influence of surgical margin status on long-term outcomes of patients undergoing adrenal resection for ACC remains not well defined. We studied the impact of surgical tumor margin status on recurrence-free survival (RFS) and overall survival (OS) of patients undergoing resection for ACC. Methods: A total of 165 patients who underwent adrenal resection for ACC and met inclusion criteria were identified form a multi-institutional database. Clinicopathological data, pathologic margin status, and long-term outcomes were assessed. Patients were stratified into two groups based on margin status: R0 (margin >1 mm) versus R1. Results: R0 resection was achieved in 126 patients (76.4 %), whereas 39 patients (23.6 %) had an R1 resection. Median and 5-year OS for patients undergoing R0 resection were 96.3 months and 64.8 % versus 25.1 months and 33.8 % for patients undergoing an R1 resection (both p 

AB - Background: The influence of surgical margin status on long-term outcomes of patients undergoing adrenal resection for ACC remains not well defined. We studied the impact of surgical tumor margin status on recurrence-free survival (RFS) and overall survival (OS) of patients undergoing resection for ACC. Methods: A total of 165 patients who underwent adrenal resection for ACC and met inclusion criteria were identified form a multi-institutional database. Clinicopathological data, pathologic margin status, and long-term outcomes were assessed. Patients were stratified into two groups based on margin status: R0 (margin >1 mm) versus R1. Results: R0 resection was achieved in 126 patients (76.4 %), whereas 39 patients (23.6 %) had an R1 resection. Median and 5-year OS for patients undergoing R0 resection were 96.3 months and 64.8 % versus 25.1 months and 33.8 % for patients undergoing an R1 resection (both p 

UR - http://www.scopus.com/inward/record.url?scp=84952628982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952628982&partnerID=8YFLogxK

U2 - 10.1245/s10434-015-4803-x

DO - 10.1245/s10434-015-4803-x

M3 - Article

VL - 23

SP - 134

EP - 141

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 1

ER -