Adrenergic dysfunction in hereditary adult-onset leukodystrophy

R. T. Brown, R. J. Polinsky, J. Schwankhaus, R. Eldridge, H. McFarland, S. Schlesinger, W. A. Dailey

Research output: Contribution to journalArticle

Abstract

We studied the pressor response to norepinephrine infusion in patients with an autosomal dominant adult-onset leukodystrophy. We also examined cardiovascular and catecholamine responses to insulin-induced hypoglycemia. A parallel shift to the left of the norepinephrine dose response curve, in conjunction with low baseline plasma norepinephrine levels, was consistent with denervation supersensitivity, suggesting a distal lesion of sympathetic nor-adrenergic neurons. Absence of the epinephrine response to insulin-induced hypoglycemia indicated that autonomic neuropathy was attended by severe adrenal medullary dysfunction.

Original languageEnglish (US)
Pages (from-to)1421-1424
Number of pages4
JournalNeurology
Volume37
Issue number8
StatePublished - 1987
Externally publishedYes

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Adrenergic Agents
Norepinephrine
Hypoglycemia
Insulin
Adrenergic Neurons
Denervation
Epinephrine
Catecholamines
Onset

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brown, R. T., Polinsky, R. J., Schwankhaus, J., Eldridge, R., McFarland, H., Schlesinger, S., & Dailey, W. A. (1987). Adrenergic dysfunction in hereditary adult-onset leukodystrophy. Neurology, 37(8), 1421-1424.

Adrenergic dysfunction in hereditary adult-onset leukodystrophy. / Brown, R. T.; Polinsky, R. J.; Schwankhaus, J.; Eldridge, R.; McFarland, H.; Schlesinger, S.; Dailey, W. A.

In: Neurology, Vol. 37, No. 8, 1987, p. 1421-1424.

Research output: Contribution to journalArticle

Brown, RT, Polinsky, RJ, Schwankhaus, J, Eldridge, R, McFarland, H, Schlesinger, S & Dailey, WA 1987, 'Adrenergic dysfunction in hereditary adult-onset leukodystrophy', Neurology, vol. 37, no. 8, pp. 1421-1424.
Brown RT, Polinsky RJ, Schwankhaus J, Eldridge R, McFarland H, Schlesinger S et al. Adrenergic dysfunction in hereditary adult-onset leukodystrophy. Neurology. 1987;37(8):1421-1424.
Brown, R. T. ; Polinsky, R. J. ; Schwankhaus, J. ; Eldridge, R. ; McFarland, H. ; Schlesinger, S. ; Dailey, W. A. / Adrenergic dysfunction in hereditary adult-onset leukodystrophy. In: Neurology. 1987 ; Vol. 37, No. 8. pp. 1421-1424.
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