Adrenergic dysfunction in hereditary adult-onset leukodystrophy

R. T. Brown, R. J. Polinsky, J. Schwankhaus, R. Eldridge, H. McFarland, S. Schlesinger, W. A. Dailey

Research output: Contribution to journalArticlepeer-review


We studied the pressor response to norepinephrine infusion in patients with an autosomal dominant adult-onset leukodystrophy. We also examined cardiovascular and catecholamine responses to insulin-induced hypoglycemia. A parallel shift to the left of the norepinephrine dose response curve, in conjunction with low baseline plasma norepinephrine levels, was consistent with denervation supersensitivity, suggesting a distal lesion of sympathetic nor-adrenergic neurons. Absence of the epinephrine response to insulin-induced hypoglycemia indicated that autonomic neuropathy was attended by severe adrenal medullary dysfunction.

Original languageEnglish (US)
Pages (from-to)1421-1424
Number of pages4
Issue number8
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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