Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control

Christopher A. Ross; David A. Ruggiero; Tong H. Joh; Dong H. Park; Donald J. Reis

doi:10.1016/0006-8993(83)90862-4

Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control

Christopher A. Ross, David A. Ruggiero, Tong H. Joh, Dong H. Park, Donald J. Reis

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or chemically elevates arterial pressure, while neuronal blockade by microinjection of tetrodotoxin bilaterally drops arterial pressure to levels comparable to those produced by spinal cord transection. Adrenaline neurons of the ventral medulla appear necessary for maintaining normal levels of blood pressure, and thus may constitute a tonic vasomotor center.

Original language	English (US)
Pages (from-to)	356-361
Number of pages	6
Journal	Brain research
Volume	273
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90862-4
State	Published - Aug 29 1983
Externally published	Yes

Keywords

adrenaline neurons
tonic vasomotor control
ventrolateral medulla

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(83)90862-4

Cite this

@article{69c008b948aa49dbb19847d5b19e94a4,

title = "Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control",

abstract = "Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or chemically elevates arterial pressure, while neuronal blockade by microinjection of tetrodotoxin bilaterally drops arterial pressure to levels comparable to those produced by spinal cord transection. Adrenaline neurons of the ventral medulla appear necessary for maintaining normal levels of blood pressure, and thus may constitute a tonic vasomotor center.",

keywords = "adrenaline neurons, tonic vasomotor control, ventrolateral medulla",

author = "Ross, {Christopher A.} and Ruggiero, {David A.} and Joh, {Tong H.} and Park, {Dong H.} and Reis, {Donald J.}",

note = "Funding Information: We thank Muhammad Anwar for excellent technical support. Research supported by grants from NIH (HL 18974; HL 07378; HL 07379).",

year = "1983",

month = aug,

day = "29",

doi = "10.1016/0006-8993(83)90862-4",

language = "English (US)",

volume = "273",

pages = "356--361",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Adrenaline synthesizing neurons in the rostral ventrolateral medulla

T2 - a possible role in tonic vasomotor control

AU - Ross, Christopher A.

AU - Ruggiero, David A.

AU - Joh, Tong H.

AU - Park, Dong H.

AU - Reis, Donald J.

N1 - Funding Information: We thank Muhammad Anwar for excellent technical support. Research supported by grants from NIH (HL 18974; HL 07378; HL 07379).

PY - 1983/8/29

Y1 - 1983/8/29

N2 - Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or chemically elevates arterial pressure, while neuronal blockade by microinjection of tetrodotoxin bilaterally drops arterial pressure to levels comparable to those produced by spinal cord transection. Adrenaline neurons of the ventral medulla appear necessary for maintaining normal levels of blood pressure, and thus may constitute a tonic vasomotor center.

AB - Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or chemically elevates arterial pressure, while neuronal blockade by microinjection of tetrodotoxin bilaterally drops arterial pressure to levels comparable to those produced by spinal cord transection. Adrenaline neurons of the ventral medulla appear necessary for maintaining normal levels of blood pressure, and thus may constitute a tonic vasomotor center.

KW - adrenaline neurons

KW - tonic vasomotor control

KW - ventrolateral medulla

UR - http://www.scopus.com/inward/record.url?scp=0020502043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020502043&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(83)90862-4

DO - 10.1016/0006-8993(83)90862-4

M3 - Article

C2 - 6616243

AN - SCOPUS:0020502043

SN - 0006-8993

VL - 273

SP - 356

EP - 361

JO - Brain research

JF - Brain research

IS - 2

ER -

Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this