Adrenaline synthesizing neurons in the rostral ventrolateral medulla

a possible role in tonic vasomotor control

Christopher A Ross, David A. Ruggiero, Tong H. Joh, Dong H. Park, Donald J. Reis

Research output: Contribution to journalArticle

Abstract

Adrenaline-containing neurons of the rostral ventrolateral medulla (the C1 group) project selectively to autonomic spinal neurons in rats. Stimulation of these neurons electrically or chemically elevates arterial pressure, while neuronal blockade by microinjection of tetrodotoxin bilaterally drops arterial pressure to levels comparable to those produced by spinal cord transection. Adrenaline neurons of the ventral medulla appear necessary for maintaining normal levels of blood pressure, and thus may constitute a tonic vasomotor center.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalBrain Research
Volume273
Issue number2
DOIs
StatePublished - Aug 29 1983
Externally publishedYes

Fingerprint

Epinephrine
Neurons
Arterial Pressure
Tetrodotoxin
Microinjections
Spinal Cord Injuries
Blood Pressure

Keywords

  • adrenaline neurons
  • tonic vasomotor control
  • ventrolateral medulla

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Adrenaline synthesizing neurons in the rostral ventrolateral medulla : a possible role in tonic vasomotor control. / Ross, Christopher A; Ruggiero, David A.; Joh, Tong H.; Park, Dong H.; Reis, Donald J.

In: Brain Research, Vol. 273, No. 2, 29.08.1983, p. 356-361.

Research output: Contribution to journalArticle

Ross, Christopher A ; Ruggiero, David A. ; Joh, Tong H. ; Park, Dong H. ; Reis, Donald J. / Adrenaline synthesizing neurons in the rostral ventrolateral medulla : a possible role in tonic vasomotor control. In: Brain Research. 1983 ; Vol. 273, No. 2. pp. 356-361.
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