TY - JOUR
T1 - Adrenal gland volume and dexamethasone-suppressed cortisol correlate with total daily salivary cortisol in African-American women
AU - Golden, Sherita Hill
AU - Malhotra, Saurabh
AU - Wand, Gary S.
AU - Brancati, Frederick L.
AU - Ford, Daniel
AU - Horton, Karen
N1 - Funding Information:
This work was supported by the Johns Hopkins University School of Medicine General Clinical Research Grant M01-RR00052 from the National Center for Research Resources/National Institutes of Health and a Patient-Oriented Mentored Scientist Award (to S.H.G.) through the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (5 K23 DK071565).
PY - 2007/4
Y1 - 2007/4
N2 - Context: Population-based studies of associations between subclinical hypercortisolism and risk for disease states, such as type 2 diabetes mellitus, have been difficult to assess because of imprecise measures of glucocorticoid exposure. Alternative measures (salivary cortisol and adrenal gland volume) have not been systematically compared with 24-h urine free cortisol (UFC) in a healthy population. Objective: Our objectives were: 1) to determine whether 24-h UFC and total daily salivary cortisol correlated with each other, adrenal gland volume, and salivary cortisol after dexamethasone suppression and 2) to evaluate the association of adrenal gland volume with salivary cortisol after dexamethasone suppression. Design, Setting, and Participants: This was a cross-sectional study of 20 healthy, premenopausal African-American women aged 18-45 yr. Main Outcome Measures: Salivary cortisol was assessed at six time points throughout the day simultaneous with 24-h UFC collection. Adrenal gland volume was measured by computed tomography scan. Dexamethasone-suppressed salivary cortisol was measured at 0800 h after administration of 0.5 mg dexamethasone at 2300 h the prior evening. Results: Dexamethasone-suppressed salivary cortisol levels correlated strongly with individual, timed salivary cortisol measurements, total daily salivary cortisol (rs = 0.75; P = 0.0001; n = 20), and adrenal gland volume (rs = 0.66; P = 0.004; n = 17). Total daily salivary cortisol and adrenal gland volume also correlated (rs = 0.46; P = 0.04; n = 19). In contrast, 24-h UFC levels did not correlate with any of the other hypothalamic-pituitary-adrenal axis measures. Conclusion: A dexamethasone suppression test or adrenal gland volume may be alternative measures for characterizing subtle subclinical hypercortisolism in healthy adults.
AB - Context: Population-based studies of associations between subclinical hypercortisolism and risk for disease states, such as type 2 diabetes mellitus, have been difficult to assess because of imprecise measures of glucocorticoid exposure. Alternative measures (salivary cortisol and adrenal gland volume) have not been systematically compared with 24-h urine free cortisol (UFC) in a healthy population. Objective: Our objectives were: 1) to determine whether 24-h UFC and total daily salivary cortisol correlated with each other, adrenal gland volume, and salivary cortisol after dexamethasone suppression and 2) to evaluate the association of adrenal gland volume with salivary cortisol after dexamethasone suppression. Design, Setting, and Participants: This was a cross-sectional study of 20 healthy, premenopausal African-American women aged 18-45 yr. Main Outcome Measures: Salivary cortisol was assessed at six time points throughout the day simultaneous with 24-h UFC collection. Adrenal gland volume was measured by computed tomography scan. Dexamethasone-suppressed salivary cortisol was measured at 0800 h after administration of 0.5 mg dexamethasone at 2300 h the prior evening. Results: Dexamethasone-suppressed salivary cortisol levels correlated strongly with individual, timed salivary cortisol measurements, total daily salivary cortisol (rs = 0.75; P = 0.0001; n = 20), and adrenal gland volume (rs = 0.66; P = 0.004; n = 17). Total daily salivary cortisol and adrenal gland volume also correlated (rs = 0.46; P = 0.04; n = 19). In contrast, 24-h UFC levels did not correlate with any of the other hypothalamic-pituitary-adrenal axis measures. Conclusion: A dexamethasone suppression test or adrenal gland volume may be alternative measures for characterizing subtle subclinical hypercortisolism in healthy adults.
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U2 - 10.1210/jc.2006-2674
DO - 10.1210/jc.2006-2674
M3 - Article
C2 - 17284636
AN - SCOPUS:34147138507
VL - 92
SP - 1358
EP - 1363
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -