TY - JOUR
T1 - Adrenal function in normal infants and in marasmus and kwashiorkor
T2 - Plasma aldosterone concentration and aldosterone secretion rate
AU - Jelliffe, Derrick B.
AU - Beitins, Inese Z.
AU - Graham, George G.
AU - Kowarski, Avinoam
AU - Migeon, Claude J.
N1 - Funding Information:
From the Departments of Pediatrics (School of Medicine) and International Health (School of Hygiene and Public Health), The Johns Hopkins University, Baltimore, Md.; and lnstituto de Investigation Nutritional, Lima, Peru. Supported by United States Public Health Service Research Grants AM-O0180 and AM-09980, Traineeship Grant Tl-AM-5219, Research Career Award 5 K06 AM-21, 855, and by Research Contract csd-2946 from the Agency for International Development. *Reprint requests: 615 North WolfeS t., Baltimore, Md. 21205.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1974/3
Y1 - 1974/3
N2 - In normal infants 2.1 to 3.2 months of age and in those 4.8 to 10.6 months of age, plasma aldosterone concentrations were, respectively, 88±42 and 61±43 ng. per 100 ml. (S.D.) and the aldosterone secretion rates were 75±21 and 70±36 μg per 24 hours. Older infants, 12.5 to 18.5 months of age, had plasma aldosterone levels of 17±7 ng. per 100 ml. and aldosterone secretion of 73±43 μg per 24 hours. The plasma aldosterone concentrations of the two younger groups were significantly higher than that of the 12.5-to 18.5-month-old children (p<0.005), but the secretion rates were similar. Six children with marasmus had plasma aldosterone levels similar to those of age or height/weight matched control infants before and after therapy. Their aldosterone secretion rates were significantly greater than those of control infants; after treatment the rates fell to normal levels. Children with kwashiorkor had plasma aldosterone concentrations which were elevated (mean±S.D. 53±50 ng. per 100 ml.) when compared to those of a control group matched for height/weight, whereas aldosterone secretion remained normal (92±98 μg per 24 hours).
AB - In normal infants 2.1 to 3.2 months of age and in those 4.8 to 10.6 months of age, plasma aldosterone concentrations were, respectively, 88±42 and 61±43 ng. per 100 ml. (S.D.) and the aldosterone secretion rates were 75±21 and 70±36 μg per 24 hours. Older infants, 12.5 to 18.5 months of age, had plasma aldosterone levels of 17±7 ng. per 100 ml. and aldosterone secretion of 73±43 μg per 24 hours. The plasma aldosterone concentrations of the two younger groups were significantly higher than that of the 12.5-to 18.5-month-old children (p<0.005), but the secretion rates were similar. Six children with marasmus had plasma aldosterone levels similar to those of age or height/weight matched control infants before and after therapy. Their aldosterone secretion rates were significantly greater than those of control infants; after treatment the rates fell to normal levels. Children with kwashiorkor had plasma aldosterone concentrations which were elevated (mean±S.D. 53±50 ng. per 100 ml.) when compared to those of a control group matched for height/weight, whereas aldosterone secretion remained normal (92±98 μg per 24 hours).
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U2 - 10.1016/S0022-3476(74)80737-7
DO - 10.1016/S0022-3476(74)80737-7
M3 - Article
C2 - 4204569
AN - SCOPUS:0015968860
VL - 84
SP - 444
EP - 451
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -