Adrenal function in normal infants and in marasmus and kwashiorkor: Plasma aldosterone concentration and aldosterone secretion rate

Derrick B. Jelliffe, Inese Z. Beitins, George G. Graham, Avinoam Kowarski, Claude J. Migeon

Research output: Contribution to journalArticle


In normal infants 2.1 to 3.2 months of age and in those 4.8 to 10.6 months of age, plasma aldosterone concentrations were, respectively, 88±42 and 61±43 ng. per 100 ml. (S.D.) and the aldosterone secretion rates were 75±21 and 70±36 μg per 24 hours. Older infants, 12.5 to 18.5 months of age, had plasma aldosterone levels of 17±7 ng. per 100 ml. and aldosterone secretion of 73±43 μg per 24 hours. The plasma aldosterone concentrations of the two younger groups were significantly higher than that of the 12.5-to 18.5-month-old children (p<0.005), but the secretion rates were similar. Six children with marasmus had plasma aldosterone levels similar to those of age or height/weight matched control infants before and after therapy. Their aldosterone secretion rates were significantly greater than those of control infants; after treatment the rates fell to normal levels. Children with kwashiorkor had plasma aldosterone concentrations which were elevated (mean±S.D. 53±50 ng. per 100 ml.) when compared to those of a control group matched for height/weight, whereas aldosterone secretion remained normal (92±98 μg per 24 hours).

Original languageEnglish (US)
Pages (from-to)444-451
Number of pages8
JournalThe Journal of pediatrics
Issue number3
StatePublished - Mar 1974


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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