Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol

Inese Z. Beitins; Avinoam Kowarski; Claude J. Migeon; George G. Graham

doi:10.1016/S0022-3476(75)80495-1

Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol

Inese Z. Beitins, Avinoam Kowarski, Claude J. Migeon, George G. Graham

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Normal infants exhibited circadian rhythmicity of plasma F concentration. Infants from 2.1 to 3.2 months of age had CSR significantly higher than those of older infants. THF/THE urinary excretion ratios increased with age. The 17OHCS excretion was higher in the younger infants. Urinary excretions of free corticoids and cortisol were similar in all age groups. In marasmus, plasma F concentrations in the morning and evening were significantly elevated. Normal diurnal variation returned following therapy. CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls. THF/THE ratios, urinary excretion of free corticoids and cortisol were normal. In marasmic kwashiorkor, plasma F concentrations were significantly elevated in the morning and evening. There was a suggestive decrease with therapy. CSR was low before and after treatment. THF/THE ratios, urinary 17OHCS excretion, and urinary free corticoids and cortisol were not significantly different from infants matched for size or patients with marasmus.

Original language	English (US)
Pages (from-to)	302-308
Number of pages	7
Journal	The Journal of pediatrics
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(75)80495-1
State	Published - Feb 1975

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(75)80495-1

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Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol. / Beitins, Inese Z.; Kowarski, Avinoam; Migeon, Claude J. et al.
In: The Journal of pediatrics, Vol. 86, No. 2, 02.1975, p. 302-308.

Research output: Contribution to journal › Article › peer-review

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title = "Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol",

abstract = "Normal infants exhibited circadian rhythmicity of plasma F concentration. Infants from 2.1 to 3.2 months of age had CSR significantly higher than those of older infants. THF/THE urinary excretion ratios increased with age. The 17OHCS excretion was higher in the younger infants. Urinary excretions of free corticoids and cortisol were similar in all age groups. In marasmus, plasma F concentrations in the morning and evening were significantly elevated. Normal diurnal variation returned following therapy. CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls. THF/THE ratios, urinary excretion of free corticoids and cortisol were normal. In marasmic kwashiorkor, plasma F concentrations were significantly elevated in the morning and evening. There was a suggestive decrease with therapy. CSR was low before and after treatment. THF/THE ratios, urinary 17OHCS excretion, and urinary free corticoids and cortisol were not significantly different from infants matched for size or patients with marasmus.",

author = "Beitins, {Inese Z.} and Avinoam Kowarski and Migeon, {Claude J.} and Graham, {George G.}",

note = "Funding Information: From the Departments of Pediatrics (School t!f Medicine) and lnternational Health (School of Hygiene and Public' Health), The Johns Hopkins University, and Instituto de lnvestigacion Nutricional, Lima, Peru. Supported by United States{"} Public Health Service Research Grants A M-O0180 and A M-09980, Traineeship Grant T-AM 5219, and Research Career A ward 5 K06 AM-21, 855, and by Research Contract csd/2946 with the Agency.for International Development, United States Department o/State. *Data for individual children are available in xelvx form from the authors. ** Reprint address: 615 North Wo\[leS t., Baltimore, Md. 21205. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1975",

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doi = "10.1016/S0022-3476(75)80495-1",

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AU - Beitins, Inese Z.

AU - Kowarski, Avinoam

AU - Migeon, Claude J.

AU - Graham, George G.

N1 - Funding Information: From the Departments of Pediatrics (School t!f Medicine) and lnternational Health (School of Hygiene and Public' Health), The Johns Hopkins University, and Instituto de lnvestigacion Nutricional, Lima, Peru. Supported by United States" Public Health Service Research Grants A M-O0180 and A M-09980, Traineeship Grant T-AM 5219, and Research Career A ward 5 K06 AM-21, 855, and by Research Contract csd/2946 with the Agency.for International Development, United States Department o/State. *Data for individual children are available in xelvx form from the authors. ** Reprint address: 615 North Wo\[leS t., Baltimore, Md. 21205. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1975/2

Y1 - 1975/2

N2 - Normal infants exhibited circadian rhythmicity of plasma F concentration. Infants from 2.1 to 3.2 months of age had CSR significantly higher than those of older infants. THF/THE urinary excretion ratios increased with age. The 17OHCS excretion was higher in the younger infants. Urinary excretions of free corticoids and cortisol were similar in all age groups. In marasmus, plasma F concentrations in the morning and evening were significantly elevated. Normal diurnal variation returned following therapy. CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls. THF/THE ratios, urinary excretion of free corticoids and cortisol were normal. In marasmic kwashiorkor, plasma F concentrations were significantly elevated in the morning and evening. There was a suggestive decrease with therapy. CSR was low before and after treatment. THF/THE ratios, urinary 17OHCS excretion, and urinary free corticoids and cortisol were not significantly different from infants matched for size or patients with marasmus.

AB - Normal infants exhibited circadian rhythmicity of plasma F concentration. Infants from 2.1 to 3.2 months of age had CSR significantly higher than those of older infants. THF/THE urinary excretion ratios increased with age. The 17OHCS excretion was higher in the younger infants. Urinary excretions of free corticoids and cortisol were similar in all age groups. In marasmus, plasma F concentrations in the morning and evening were significantly elevated. Normal diurnal variation returned following therapy. CSR and 17OHCS excretions were not different from age controls, but were significantly lower than size controls. THF/THE ratios, urinary excretion of free corticoids and cortisol were normal. In marasmic kwashiorkor, plasma F concentrations were significantly elevated in the morning and evening. There was a suggestive decrease with therapy. CSR was low before and after treatment. THF/THE ratios, urinary 17OHCS excretion, and urinary free corticoids and cortisol were not significantly different from infants matched for size or patients with marasmus.

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Adrenal function in normal infants and in marasmus and kwashiorkor. Cortisol secretion, diurnal variation of plasma cortisol, and urinary excretion of 17-hydroxycorticoids, free corticoids, and cortisol

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