TY - JOUR
T1 - Adoptive immunotherapy for cancer
T2 - Building on success
AU - Gattinoni, Luca
AU - Powell, Daniel J.
AU - Rosenberg, Steven A.
AU - Restifo, Nicholas P.
N1 - Funding Information:
This work was supported by the Intramural Research Program of the Center for Cancer Research, NCI, NIH. The authors would like to thank all the members of the translational immunology team at the NCI especially M. E. Dudley, J. C. Yang, P. F. Robbins, R. A. Morgan, R. M. Sherry, M. R. Parkhurst, J. R Wunderlich and S. L. Topalian.
PY - 2006/5
Y1 - 2006/5
N2 - Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.
AB - Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.
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U2 - 10.1038/nri1842
DO - 10.1038/nri1842
M3 - Review article
C2 - 16622476
AN - SCOPUS:33646356996
SN - 1474-1733
VL - 6
SP - 383
EP - 393
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 5
ER -