Adoptive immunotherapy for cancer: Building on success

Luca Gattinoni, Daniel J. Powell, Steven A. Rosenberg, Nicholas P. Restifo

Research output: Contribution to journalReview article

Abstract

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.

Original languageEnglish (US)
Pages (from-to)383-393
Number of pages11
JournalNature Reviews Immunology
Volume6
Issue number5
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Gattinoni, L., Powell, D. J., Rosenberg, S. A., & Restifo, N. P. (2006). Adoptive immunotherapy for cancer: Building on success. Nature Reviews Immunology, 6(5), 383-393. https://doi.org/10.1038/nri1842