TY - JOUR
T1 - Adoptive cell transfer as personalized immunotherapy for human cancer
AU - Rosenberg, Steven A.
AU - Restifo, Nicholas P.
PY - 2015/4/3
Y1 - 2015/4/3
N2 - Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to each cancer. These results have expanded the reach of ACT to the treatment of common epithelial cancers. In addition, the ability to genetically engineer lymphocytes to express conventional T cell receptors or chimeric antigen receptors has further extended the successful application of ACT for cancer treatment.
AB - Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to each cancer. These results have expanded the reach of ACT to the treatment of common epithelial cancers. In addition, the ability to genetically engineer lymphocytes to express conventional T cell receptors or chimeric antigen receptors has further extended the successful application of ACT for cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84928759208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928759208&partnerID=8YFLogxK
U2 - 10.1126/science.aaa4967
DO - 10.1126/science.aaa4967
M3 - Review article
C2 - 25838374
AN - SCOPUS:84928759208
SN - 0036-8075
VL - 348
SP - 62
EP - 68
JO - Science
JF - Science
IS - 6230
ER -