Abstract
Objectives: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda. Study design: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. Methods: Annual enumeration and behavioral/serological survey of all consenting adolescents aged 13-19 years at recruitment, residing in 31 randomly selected community clusters. Results: At baseline, of 909 adolescents present in study clusters, 824 (90.6%) provided interview data and serological samples. No adolescents aged 13-14 years were HIV-infected. Among those aged 15-19 years, 1.8% of men and 19.0% of women were HIV-positive. Among young women aged 15-19 years in marital/consensual union, 21.3% were HIV-positive; this rate did not differ significantly from the 29.1% prevalence in those reporting non-permanent relationships; prevalence was significantly lower in women reporting no current relationship (4.3%). After multivariate adjustment, female sex, age 17-19 years, residence in trading centers/trading villages and a history of sexually transmitted disease symptoms remained significantly associated with HIV infection. Seventy-nine per cent of adolescents provided a follow-up serological sample. No young men aged 13-14 years seroconverted during the study; in young women aged 13-14 years, HIV seroincidence was 0.6 per 100 person-years (PY) of observation. Among young men aged 15-19 years, there were 1.1 ± 0.6 seroconversions per 100 PY of observation prior to age 21 years; among women 15-19 years, the incidence rate was 3.9 ± 1.0 per 100 PY of observation prior to age 21 years. The mortality rate among HIV-positive adolescents aged 15-19 years, at 3.9 per 100 PY of observation, was 13-fold higher than that among the HIV-uninfected. By 1992, knowledge of sexual transmission was almost universal, the proportions reporting multiple partners had decreased and condom use had increased over baseline. Conclusions: Adolescents, and young women in particular, are vulnerable to HIV infection. Despite reported behavioral changes, HIV incidence rates remain substantial, and there is a need for innovative HIV preventive measures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 791-799 |
| Number of pages | 9 |
| Journal | AIDS |
| Volume | 11 |
| Issue number | 6 |
| State | Published - 1997 |
Fingerprint
Keywords
- Adolescents
- HIV
- Incidence
- Prevalence
- Sexual behaviors
- Uganda
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Adolescents, sexual behavior and HIV-1 in rural Rakai district, Uganda. / Konde-Lule, Joseph K.; Wawer, Maria J; Sewankambo, Nelson K.; Serwadda, David; Kelly, Robert; Li, Chuanjun; Gray, Ronald H; Kigongo, David.
In: AIDS, Vol. 11, No. 6, 1997, p. 791-799.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adolescents, sexual behavior and HIV-1 in rural Rakai district, Uganda
AU - Konde-Lule, Joseph K.
AU - Wawer, Maria J
AU - Sewankambo, Nelson K.
AU - Serwadda, David
AU - Kelly, Robert
AU - Li, Chuanjun
AU - Gray, Ronald H
AU - Kigongo, David
PY - 1997
Y1 - 1997
N2 - Objectives: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda. Study design: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. Methods: Annual enumeration and behavioral/serological survey of all consenting adolescents aged 13-19 years at recruitment, residing in 31 randomly selected community clusters. Results: At baseline, of 909 adolescents present in study clusters, 824 (90.6%) provided interview data and serological samples. No adolescents aged 13-14 years were HIV-infected. Among those aged 15-19 years, 1.8% of men and 19.0% of women were HIV-positive. Among young women aged 15-19 years in marital/consensual union, 21.3% were HIV-positive; this rate did not differ significantly from the 29.1% prevalence in those reporting non-permanent relationships; prevalence was significantly lower in women reporting no current relationship (4.3%). After multivariate adjustment, female sex, age 17-19 years, residence in trading centers/trading villages and a history of sexually transmitted disease symptoms remained significantly associated with HIV infection. Seventy-nine per cent of adolescents provided a follow-up serological sample. No young men aged 13-14 years seroconverted during the study; in young women aged 13-14 years, HIV seroincidence was 0.6 per 100 person-years (PY) of observation. Among young men aged 15-19 years, there were 1.1 ± 0.6 seroconversions per 100 PY of observation prior to age 21 years; among women 15-19 years, the incidence rate was 3.9 ± 1.0 per 100 PY of observation prior to age 21 years. The mortality rate among HIV-positive adolescents aged 15-19 years, at 3.9 per 100 PY of observation, was 13-fold higher than that among the HIV-uninfected. By 1992, knowledge of sexual transmission was almost universal, the proportions reporting multiple partners had decreased and condom use had increased over baseline. Conclusions: Adolescents, and young women in particular, are vulnerable to HIV infection. Despite reported behavioral changes, HIV incidence rates remain substantial, and there is a need for innovative HIV preventive measures.
AB - Objectives: To describe the epidemiology of HIV-1 infection among adolescents aged 13-19 years, in rural Rakai district, Uganda. Study design: Baseline survey and 2-year follow-up (1990-1992) of adolescents in a population-based, open rural cohort. Methods: Annual enumeration and behavioral/serological survey of all consenting adolescents aged 13-19 years at recruitment, residing in 31 randomly selected community clusters. Results: At baseline, of 909 adolescents present in study clusters, 824 (90.6%) provided interview data and serological samples. No adolescents aged 13-14 years were HIV-infected. Among those aged 15-19 years, 1.8% of men and 19.0% of women were HIV-positive. Among young women aged 15-19 years in marital/consensual union, 21.3% were HIV-positive; this rate did not differ significantly from the 29.1% prevalence in those reporting non-permanent relationships; prevalence was significantly lower in women reporting no current relationship (4.3%). After multivariate adjustment, female sex, age 17-19 years, residence in trading centers/trading villages and a history of sexually transmitted disease symptoms remained significantly associated with HIV infection. Seventy-nine per cent of adolescents provided a follow-up serological sample. No young men aged 13-14 years seroconverted during the study; in young women aged 13-14 years, HIV seroincidence was 0.6 per 100 person-years (PY) of observation. Among young men aged 15-19 years, there were 1.1 ± 0.6 seroconversions per 100 PY of observation prior to age 21 years; among women 15-19 years, the incidence rate was 3.9 ± 1.0 per 100 PY of observation prior to age 21 years. The mortality rate among HIV-positive adolescents aged 15-19 years, at 3.9 per 100 PY of observation, was 13-fold higher than that among the HIV-uninfected. By 1992, knowledge of sexual transmission was almost universal, the proportions reporting multiple partners had decreased and condom use had increased over baseline. Conclusions: Adolescents, and young women in particular, are vulnerable to HIV infection. Despite reported behavioral changes, HIV incidence rates remain substantial, and there is a need for innovative HIV preventive measures.
KW - Adolescents
KW - HIV
KW - Incidence
KW - Prevalence
KW - Sexual behaviors
KW - Uganda
UR - http://www.scopus.com/inward/record.url?scp=0030612507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030612507&partnerID=8YFLogxK
M3 - Article
C2 - 9143612
AN - SCOPUS:0030612507
VL - 11
SP - 791
EP - 799
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 6
ER -