Abstract
Youth with elevated psychopathic traits exhibit a number of comparable neurocognitive deficits as adult psychopathic offenders, including error-related processing deficits. Subregions of the basal ganglia play an important, though indirect, role in error-related processing through connections with cortical areas including the anterior cingulate cortex. A number of recent structural and functional magnetic resonance imaging (s/fMRI) studies have associated basal ganglia dysfunction in youth with elevated psychopathic traits, but these studies have not examined whether dysfunction occurring within subregions of the basal ganglia help contribute to error-related processing deficits previously observed in such at-risk youth. Here, we investigated error-related processing using a response inhibition Go/NoGo fMRI experimental paradigm in a large sample of incarcerated male adolescent offenders (n = 182). In the current report, psychopathy scores (measured via the Psychopathy Checklist: Youth Version (PCL:YV)) were negatively related to hemodynamic activity within input nuclei of the basal ganglia (i.e., the caudate and nucleus accumbens), as well as intrinsic/output nuclei (i.e., the globus pallidus and substantia nigra) and related nuclei (i.e., the subthalamic nucleus) during error-related processing. This is the first evidence to suggest that error-related dysfunction previously observed in youth with elevated psychopathic traits may be related to underlying abnormalities occurring within subregions of the basal ganglia.
| Original language | English (US) |
|---|---|
| Journal | Journal of Abnormal Child Psychology |
| DOIs | |
| State | Published - Jan 1 2019 |
| Externally published | Yes |
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Keywords
- Basal ganglia
- Callous-unemotional traits
- Error-related processing
- Functional magnetic resonance imaging
- Juvenile delinquency
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Psychiatry and Mental health
Cite this
Adolescent Psychopathic Traits Negatively Relate to Hemodynamic Activity within the Basal Ganglia during Error-Related Processing. / Maurer, J. Michael; Steele, Vaughn R.; Vincent, Gina M.; Rao, Vikram; Calhoun, Vince Daniel; Kiehl, Kent A.
In: Journal of Abnormal Child Psychology, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Adolescent Psychopathic Traits Negatively Relate to Hemodynamic Activity within the Basal Ganglia during Error-Related Processing
AU - Maurer, J. Michael
AU - Steele, Vaughn R.
AU - Vincent, Gina M.
AU - Rao, Vikram
AU - Calhoun, Vince Daniel
AU - Kiehl, Kent A.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Youth with elevated psychopathic traits exhibit a number of comparable neurocognitive deficits as adult psychopathic offenders, including error-related processing deficits. Subregions of the basal ganglia play an important, though indirect, role in error-related processing through connections with cortical areas including the anterior cingulate cortex. A number of recent structural and functional magnetic resonance imaging (s/fMRI) studies have associated basal ganglia dysfunction in youth with elevated psychopathic traits, but these studies have not examined whether dysfunction occurring within subregions of the basal ganglia help contribute to error-related processing deficits previously observed in such at-risk youth. Here, we investigated error-related processing using a response inhibition Go/NoGo fMRI experimental paradigm in a large sample of incarcerated male adolescent offenders (n = 182). In the current report, psychopathy scores (measured via the Psychopathy Checklist: Youth Version (PCL:YV)) were negatively related to hemodynamic activity within input nuclei of the basal ganglia (i.e., the caudate and nucleus accumbens), as well as intrinsic/output nuclei (i.e., the globus pallidus and substantia nigra) and related nuclei (i.e., the subthalamic nucleus) during error-related processing. This is the first evidence to suggest that error-related dysfunction previously observed in youth with elevated psychopathic traits may be related to underlying abnormalities occurring within subregions of the basal ganglia.
AB - Youth with elevated psychopathic traits exhibit a number of comparable neurocognitive deficits as adult psychopathic offenders, including error-related processing deficits. Subregions of the basal ganglia play an important, though indirect, role in error-related processing through connections with cortical areas including the anterior cingulate cortex. A number of recent structural and functional magnetic resonance imaging (s/fMRI) studies have associated basal ganglia dysfunction in youth with elevated psychopathic traits, but these studies have not examined whether dysfunction occurring within subregions of the basal ganglia help contribute to error-related processing deficits previously observed in such at-risk youth. Here, we investigated error-related processing using a response inhibition Go/NoGo fMRI experimental paradigm in a large sample of incarcerated male adolescent offenders (n = 182). In the current report, psychopathy scores (measured via the Psychopathy Checklist: Youth Version (PCL:YV)) were negatively related to hemodynamic activity within input nuclei of the basal ganglia (i.e., the caudate and nucleus accumbens), as well as intrinsic/output nuclei (i.e., the globus pallidus and substantia nigra) and related nuclei (i.e., the subthalamic nucleus) during error-related processing. This is the first evidence to suggest that error-related dysfunction previously observed in youth with elevated psychopathic traits may be related to underlying abnormalities occurring within subregions of the basal ganglia.
KW - Basal ganglia
KW - Callous-unemotional traits
KW - Error-related processing
KW - Functional magnetic resonance imaging
KW - Juvenile delinquency
UR - http://www.scopus.com/inward/record.url?scp=85066094264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066094264&partnerID=8YFLogxK
U2 - 10.1007/s10802-019-00560-3
DO - 10.1007/s10802-019-00560-3
M3 - Article
C2 - 31104203
AN - SCOPUS:85066094264
JO - Journal of Abnormal Child Psychology
JF - Journal of Abnormal Child Psychology
SN - 0091-0627
ER -