Adolescent Psychopathic Traits Negatively Relate to Hemodynamic Activity within the Basal Ganglia during Error-Related Processing

J. Michael Maurer, Vaughn R. Steele, Gina M. Vincent, Vikram Rao, Vince Daniel Calhoun, Kent A. Kiehl

Research output: Contribution to journalArticle

Abstract

Youth with elevated psychopathic traits exhibit a number of comparable neurocognitive deficits as adult psychopathic offenders, including error-related processing deficits. Subregions of the basal ganglia play an important, though indirect, role in error-related processing through connections with cortical areas including the anterior cingulate cortex. A number of recent structural and functional magnetic resonance imaging (s/fMRI) studies have associated basal ganglia dysfunction in youth with elevated psychopathic traits, but these studies have not examined whether dysfunction occurring within subregions of the basal ganglia help contribute to error-related processing deficits previously observed in such at-risk youth. Here, we investigated error-related processing using a response inhibition Go/NoGo fMRI experimental paradigm in a large sample of incarcerated male adolescent offenders (n = 182). In the current report, psychopathy scores (measured via the Psychopathy Checklist: Youth Version (PCL:YV)) were negatively related to hemodynamic activity within input nuclei of the basal ganglia (i.e., the caudate and nucleus accumbens), as well as intrinsic/output nuclei (i.e., the globus pallidus and substantia nigra) and related nuclei (i.e., the subthalamic nucleus) during error-related processing. This is the first evidence to suggest that error-related dysfunction previously observed in youth with elevated psychopathic traits may be related to underlying abnormalities occurring within subregions of the basal ganglia.

Original languageEnglish (US)
JournalJournal of Abnormal Child Psychology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Basal Ganglia
Hemodynamics
Magnetic Resonance Imaging
Subthalamic Nucleus
Globus Pallidus
Caudate Nucleus
Gyrus Cinguli
Nucleus Accumbens
Substantia Nigra
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Keywords

  • Basal ganglia
  • Callous-unemotional traits
  • Error-related processing
  • Functional magnetic resonance imaging
  • Juvenile delinquency

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Adolescent Psychopathic Traits Negatively Relate to Hemodynamic Activity within the Basal Ganglia during Error-Related Processing. / Maurer, J. Michael; Steele, Vaughn R.; Vincent, Gina M.; Rao, Vikram; Calhoun, Vince Daniel; Kiehl, Kent A.

In: Journal of Abnormal Child Psychology, 01.01.2019.

Research output: Contribution to journalArticle

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