Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: Results of the dietary intervention study in children follow-up study

Joanne F. Dorgan, Lea Liu, Catherine Klifa, Nola Hylton, John A. Shepherd, Frank Z. Stanczyk, Linda G. Snetselaar, Linda Van Horn, Victor J. Stevens, Alan Robson, Peter O. Kwiterovich, Norman L. Lasser, John H. Himes, Kelley Pettee Gabriel, Andrea Kriska, Elizabeth H. Ruder, Carolyn Y. Fang, Bruce A. Barton

Research output: Contribution to journalArticle

Abstract

Background: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. Methods: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. Results: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Conclusions: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. Impact: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured.

Original languageEnglish (US)
Pages (from-to)1545-1556
Number of pages12
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number6
DOIs
StatePublished - 2010

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Bone Density
Hormones
Diet
Fats
Breast Neoplasms
Serum
Progesterone
Estradiol
Biomarkers
Luteal Phase
Breast Density
Therapeutics

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Medicine(all)

Cite this

Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women : Results of the dietary intervention study in children follow-up study. / Dorgan, Joanne F.; Liu, Lea; Klifa, Catherine; Hylton, Nola; Shepherd, John A.; Stanczyk, Frank Z.; Snetselaar, Linda G.; Van Horn, Linda; Stevens, Victor J.; Robson, Alan; Kwiterovich, Peter O.; Lasser, Norman L.; Himes, John H.; Gabriel, Kelley Pettee; Kriska, Andrea; Ruder, Elizabeth H.; Fang, Carolyn Y.; Barton, Bruce A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 19, No. 6, 2010, p. 1545-1556.

Research output: Contribution to journalArticle

Dorgan, JF, Liu, L, Klifa, C, Hylton, N, Shepherd, JA, Stanczyk, FZ, Snetselaar, LG, Van Horn, L, Stevens, VJ, Robson, A, Kwiterovich, PO, Lasser, NL, Himes, JH, Gabriel, KP, Kriska, A, Ruder, EH, Fang, CY & Barton, BA 2010, 'Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: Results of the dietary intervention study in children follow-up study', Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 6, pp. 1545-1556. https://doi.org/10.1158/1055-9965.EPI-09-1259
Dorgan, Joanne F. ; Liu, Lea ; Klifa, Catherine ; Hylton, Nola ; Shepherd, John A. ; Stanczyk, Frank Z. ; Snetselaar, Linda G. ; Van Horn, Linda ; Stevens, Victor J. ; Robson, Alan ; Kwiterovich, Peter O. ; Lasser, Norman L. ; Himes, John H. ; Gabriel, Kelley Pettee ; Kriska, Andrea ; Ruder, Elizabeth H. ; Fang, Carolyn Y. ; Barton, Bruce A. / Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women : Results of the dietary intervention study in children follow-up study. In: Cancer Epidemiology Biomarkers and Prevention. 2010 ; Vol. 19, No. 6. pp. 1545-1556.
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abstract = "Background: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. Methods: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. Results: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Conclusions: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. Impact: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured.",
author = "Dorgan, {Joanne F.} and Lea Liu and Catherine Klifa and Nola Hylton and Shepherd, {John A.} and Stanczyk, {Frank Z.} and Snetselaar, {Linda G.} and {Van Horn}, Linda and Stevens, {Victor J.} and Alan Robson and Kwiterovich, {Peter O.} and Lasser, {Norman L.} and Himes, {John H.} and Gabriel, {Kelley Pettee} and Andrea Kriska and Ruder, {Elizabeth H.} and Fang, {Carolyn Y.} and Barton, {Bruce A.}",
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T1 - Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women

T2 - Results of the dietary intervention study in children follow-up study

AU - Dorgan, Joanne F.

AU - Liu, Lea

AU - Klifa, Catherine

AU - Hylton, Nola

AU - Shepherd, John A.

AU - Stanczyk, Frank Z.

AU - Snetselaar, Linda G.

AU - Van Horn, Linda

AU - Stevens, Victor J.

AU - Robson, Alan

AU - Kwiterovich, Peter O.

AU - Lasser, Norman L.

AU - Himes, John H.

AU - Gabriel, Kelley Pettee

AU - Kriska, Andrea

AU - Ruder, Elizabeth H.

AU - Fang, Carolyn Y.

AU - Barton, Bruce A.

PY - 2010

Y1 - 2010

N2 - Background: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. Methods: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. Results: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Conclusions: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. Impact: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured.

AB - Background: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. Methods: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. Results: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Conclusions: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. Impact: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured.

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