Adolescent diet and metabolic syndrome in young women: Results of the Dietary Intervention Study in Children (DISC) follow-up study

Joanne F. Dorgan, Lea Liu, Bruce A. Barton, Snehal Deshmukh, Linda G. Snetselaar, Linda Van Horn, Victor J. Stevens, Alan M. Robson, Norman L. Lasser, John H. Himes, John A. Shepherd, Ray Pourfarzib, Kelley Pettee Gabriel, Andrea Kriska, Peter O. Kwiterovich

Research output: Contribution to journalArticle

Abstract

Context: Childhood diet is hypothesized to influence development of chronic disease in adulthood. Objective: Our objective was to evaluate the long-term effects of a dietary intervention to reduce fat and increase fiber intake during childhood and adolescence on the prevalence of metabolic syndrome in young adult women. Design: A follow-up study was conducted in 2006-2008, 9 yr after termination of the Dietary Intervention Study in Children (DISC). Setting: The study took place at six DISC clinical centers in the United States. Participants: A total of 230 (76%) DISC female participantswhowere 25-29 yr old and had not been pregnant or breastfeeding in the previous 3 months participated in the follow-up study. Intervention: There was no intervention between the end of the DISC trial and the follow-up visit. Main Outcome Measure: Metabolic syndrome was the primary study endpoint planned before data collection and was hypothesized to be less common in the intervention group participants. Results: Metabolic syndrome was uncommon, and its prevalence did not differ by treatment group. However, after adjustment for nondietary variables, mean systolic blood pressures of intervention and control group participants were 107.7 and 110.0 mm Hg, respectively (P = 0.03), whereas mean fasting plasma glucose levels were 87.0 and 89.1 mg/dl, respectively (P = 0.01). Intervention group participants also had lower concentrations of large very-low-density lipoprotein particles, a marker of hepatic insulin resistance, compared with control group participants. Adjustment for current diet did not materially alter results. Conclusion: Consumption of a diet lower in fat and higher in fiber during childhood and adolescence may benefit glycemic control and blood pressure long term.

Original languageEnglish (US)
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number12
DOIs
StatePublished - Dec 2011

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Nutrition
Blood pressure
Diet
Blood Pressure
Fats
VLDL Lipoproteins
Fibers
Control Groups
Breast Feeding
Insulin
Plasmas
Insulin Resistance
Glucose
Young Adult
Fasting
Chronic Disease
Outcome Assessment (Health Care)
Young Syndrome
Liver
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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Adolescent diet and metabolic syndrome in young women : Results of the Dietary Intervention Study in Children (DISC) follow-up study. / Dorgan, Joanne F.; Liu, Lea; Barton, Bruce A.; Deshmukh, Snehal; Snetselaar, Linda G.; Van Horn, Linda; Stevens, Victor J.; Robson, Alan M.; Lasser, Norman L.; Himes, John H.; Shepherd, John A.; Pourfarzib, Ray; Gabriel, Kelley Pettee; Kriska, Andrea; Kwiterovich, Peter O.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 12, 12.2011.

Research output: Contribution to journalArticle

Dorgan, JF, Liu, L, Barton, BA, Deshmukh, S, Snetselaar, LG, Van Horn, L, Stevens, VJ, Robson, AM, Lasser, NL, Himes, JH, Shepherd, JA, Pourfarzib, R, Gabriel, KP, Kriska, A & Kwiterovich, PO 2011, 'Adolescent diet and metabolic syndrome in young women: Results of the Dietary Intervention Study in Children (DISC) follow-up study', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 12. https://doi.org/10.1210/jc.2010-2726
Dorgan, Joanne F. ; Liu, Lea ; Barton, Bruce A. ; Deshmukh, Snehal ; Snetselaar, Linda G. ; Van Horn, Linda ; Stevens, Victor J. ; Robson, Alan M. ; Lasser, Norman L. ; Himes, John H. ; Shepherd, John A. ; Pourfarzib, Ray ; Gabriel, Kelley Pettee ; Kriska, Andrea ; Kwiterovich, Peter O. / Adolescent diet and metabolic syndrome in young women : Results of the Dietary Intervention Study in Children (DISC) follow-up study. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 12.
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abstract = "Context: Childhood diet is hypothesized to influence development of chronic disease in adulthood. Objective: Our objective was to evaluate the long-term effects of a dietary intervention to reduce fat and increase fiber intake during childhood and adolescence on the prevalence of metabolic syndrome in young adult women. Design: A follow-up study was conducted in 2006-2008, 9 yr after termination of the Dietary Intervention Study in Children (DISC). Setting: The study took place at six DISC clinical centers in the United States. Participants: A total of 230 (76{\%}) DISC female participantswhowere 25-29 yr old and had not been pregnant or breastfeeding in the previous 3 months participated in the follow-up study. Intervention: There was no intervention between the end of the DISC trial and the follow-up visit. Main Outcome Measure: Metabolic syndrome was the primary study endpoint planned before data collection and was hypothesized to be less common in the intervention group participants. Results: Metabolic syndrome was uncommon, and its prevalence did not differ by treatment group. However, after adjustment for nondietary variables, mean systolic blood pressures of intervention and control group participants were 107.7 and 110.0 mm Hg, respectively (P = 0.03), whereas mean fasting plasma glucose levels were 87.0 and 89.1 mg/dl, respectively (P = 0.01). Intervention group participants also had lower concentrations of large very-low-density lipoprotein particles, a marker of hepatic insulin resistance, compared with control group participants. Adjustment for current diet did not materially alter results. Conclusion: Consumption of a diet lower in fat and higher in fiber during childhood and adolescence may benefit glycemic control and blood pressure long term.",
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T2 - Results of the Dietary Intervention Study in Children (DISC) follow-up study

AU - Dorgan, Joanne F.

AU - Liu, Lea

AU - Barton, Bruce A.

AU - Deshmukh, Snehal

AU - Snetselaar, Linda G.

AU - Van Horn, Linda

AU - Stevens, Victor J.

AU - Robson, Alan M.

AU - Lasser, Norman L.

AU - Himes, John H.

AU - Shepherd, John A.

AU - Pourfarzib, Ray

AU - Gabriel, Kelley Pettee

AU - Kriska, Andrea

AU - Kwiterovich, Peter O.

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N2 - Context: Childhood diet is hypothesized to influence development of chronic disease in adulthood. Objective: Our objective was to evaluate the long-term effects of a dietary intervention to reduce fat and increase fiber intake during childhood and adolescence on the prevalence of metabolic syndrome in young adult women. Design: A follow-up study was conducted in 2006-2008, 9 yr after termination of the Dietary Intervention Study in Children (DISC). Setting: The study took place at six DISC clinical centers in the United States. Participants: A total of 230 (76%) DISC female participantswhowere 25-29 yr old and had not been pregnant or breastfeeding in the previous 3 months participated in the follow-up study. Intervention: There was no intervention between the end of the DISC trial and the follow-up visit. Main Outcome Measure: Metabolic syndrome was the primary study endpoint planned before data collection and was hypothesized to be less common in the intervention group participants. Results: Metabolic syndrome was uncommon, and its prevalence did not differ by treatment group. However, after adjustment for nondietary variables, mean systolic blood pressures of intervention and control group participants were 107.7 and 110.0 mm Hg, respectively (P = 0.03), whereas mean fasting plasma glucose levels were 87.0 and 89.1 mg/dl, respectively (P = 0.01). Intervention group participants also had lower concentrations of large very-low-density lipoprotein particles, a marker of hepatic insulin resistance, compared with control group participants. Adjustment for current diet did not materially alter results. Conclusion: Consumption of a diet lower in fat and higher in fiber during childhood and adolescence may benefit glycemic control and blood pressure long term.

AB - Context: Childhood diet is hypothesized to influence development of chronic disease in adulthood. Objective: Our objective was to evaluate the long-term effects of a dietary intervention to reduce fat and increase fiber intake during childhood and adolescence on the prevalence of metabolic syndrome in young adult women. Design: A follow-up study was conducted in 2006-2008, 9 yr after termination of the Dietary Intervention Study in Children (DISC). Setting: The study took place at six DISC clinical centers in the United States. Participants: A total of 230 (76%) DISC female participantswhowere 25-29 yr old and had not been pregnant or breastfeeding in the previous 3 months participated in the follow-up study. Intervention: There was no intervention between the end of the DISC trial and the follow-up visit. Main Outcome Measure: Metabolic syndrome was the primary study endpoint planned before data collection and was hypothesized to be less common in the intervention group participants. Results: Metabolic syndrome was uncommon, and its prevalence did not differ by treatment group. However, after adjustment for nondietary variables, mean systolic blood pressures of intervention and control group participants were 107.7 and 110.0 mm Hg, respectively (P = 0.03), whereas mean fasting plasma glucose levels were 87.0 and 89.1 mg/dl, respectively (P = 0.01). Intervention group participants also had lower concentrations of large very-low-density lipoprotein particles, a marker of hepatic insulin resistance, compared with control group participants. Adjustment for current diet did not materially alter results. Conclusion: Consumption of a diet lower in fat and higher in fiber during childhood and adolescence may benefit glycemic control and blood pressure long term.

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